6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole

Base Information

Chemical Name:6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole
CAS No.:72873-74-6
Molecular Formula:C16H12 F N3 S
Molecular Weight:297.356
Hs Code.:2934100090
European Community (EC) Number:635-291-9
UNII:9R6QDF1UO7
DSSTox Substance ID:DTXSID70223168
Nikkaji Number:J247.967B
Wikidata:Q27088814
Pharos Ligand ID:CGS9HSYPWAK9
ChEMBL ID:CHEMBL313417
Mol file:72873-74-6.mol

Synonyms:6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole;SK and F 86002;SK and F 86002-A(2);SKF 86002;SKF86002

Suppliers and Price of 6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
SKF 86002 dihydrochloride
10mg
$ 466.00

TRC
SKF-86002
5mg
$ 130.00

Sigma-Aldrich
SKF-86002 ≥98% (HPLC), solid
5mg
$ 191.00

Sigma-Aldrich
SKF-86002
5mg
$ 161.87

DC Chemicals
SKF-86002 >98%
100 mg
$ 450.00

DC Chemicals
SKF-86002 >98%
250 mg
$ 900.00

CSNpharm
SKF-86002
2mg
$ 91.00

Crysdot
SKF-86002 98+%
50mg
$ 860.00

Crysdot
SKF-86002 98+%
10mg
$ 216.00

ChemScene
SKF-86002 99.46%
10mg
$ 252.00

Total 25 raw suppliers

Chemical Property of 6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole

Chemical Property:

Vapor Pressure:3.14E-09mmHg at 25°C
Melting Point:189-190 °C(lit.)
Boiling Point:476.1°C at 760 mmHg
PKA:4.36±0.10(Predicted)
Flash Point:241.7°C
PSA：56.01000
Density:1.39±0.1 g/cm3(Predicted)
LogP:3.85690
Storage Temp.:2-8°C
Solubility.:DMSO: 9 mg/mL, soluble
XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:297.07359673
Heavy Atom Count:21
Complexity:355

Purity/Quality:

99%, ^*data from raw suppliers

SKF 86002 dihydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1CSC2=NC(=C(N21)C3=CC=NC=C3)C4=CC=C(C=C4)F
Description SKF 86002 is an anti-inflammatory agent. It inhibits rat seminal vesicle prostaglandin H2 (PGH2) synthase (IC50 = 120 μM), as well as prostanoid production by rat basophilic leukemia (RBL-1) cells and human monocytes (IC50s = 70 and 1 μM, respectively). SKF 86002 inhibits leukotriene B4 (LTB4) and LTC4 production induced by A23187 in human neutrophils and monocytes, respectively (IC50 = 20 μM for both). It also inhibits LPS-induced IL-1 production in human monocytes (IC50 = 1.3 μM). SKF 86002 (10, 30, and 90 mg/kg) reduces hindleg volume in rat models of adjuvant- or collagen-induced arthritis. It also decreases serum levels of TNF-α and increases survival in a mouse model of LPS and galactosamine-induced endotoxic shock when administered at a dose of 100 mg/kg.
Uses SKF 86002 is an inhibitor of p53, Cox, and 5-LO.

Technology Process of 6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole

There total 6 articles about 6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 106465-75-2
5-(N-ethoxycarbonyl-1,4-dihydro-pyridin-4-yl)-6-(4-fluorophenyl)-2,3-dihydroimidazo[2,1-b]-thiazole

: 72873-74-6
5-(4-pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo[2,1-b]thiazole

Guidance literature:: With sulfur; In 1,3,5-trimethyl-benzene; for 2h; Heating;
DOI:10.1021/jo00253a012

Reference yield:

: 87532-41-0
1-(4-Fluoro-phenyl)-2-hydroxy-2-pyridin-4-yl-ethanone

: 72873-74-6
5-(4-pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo[2,1-b]thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / dimethylformamide / 4 h / Heating

2: 1.) NaH, 2.) K₂CO₃ / 1.) DMF, RT, 0.5 h, 2.) DMF, a) overnight, b) reflux, 1.5 h

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00367a014

Reference yield:

: 110-86-1
pyridine

: 72873-74-6
5-(4-pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo[2,1-b]thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / CH₂Cl₂ / 0 - 20 °C

2: 92 percent / S / 1,3,5-trimethyl-benzene / 2 h / Heating

With sulfur; In dichloromethane; 1,3,5-trimethyl-benzene;
DOI:10.1021/jo00253a012