5,8-Dimethoxy-2-(2-hydroxyethyl)amino-3-hydroxy-1,2,3,4-tetrahydronaphthalene

Base Information

• Chemical Name: 5,8-Dimethoxy-2-(2-hydroxyethyl)amino-3-hydroxy-1,2,3,4-tetrahydronaphthalene
• CAS No.: 64831-69-2
• Molecular Formula: C₁₄H₂₁NO₄
• Molecular Weight: 267.325
• DSSTox Substance ID: DTXSID00983425
• Nikkaji Number: J389.165H
• Wikidata: Q82970350
• Mol file: 64831-69-2.mol

Synonyms:5,8-dimethoxy-2-(2-hydroxyethyl)amino-3-hydroxy-1,2,3,4-tetrahydronaphthalene;5,8-dimethoxy-2-(2-hydroxyethyl)amino-3-hydroxy-1,2,3,4-tetrahydronaphthalene, hydrochloride, (trans)-isomer;5,8-dimethoxy-trans-2-(2-hydroxyethyl)amino-3-hydroxy-1,2,3,4-tetrahydronaphthalene;tetraminol

Chemical Property of 5,8-Dimethoxy-2-(2-hydroxyethyl)amino-3-hydroxy-1,2,3,4-tetrahydronaphthalene

Chemical Property:

• Vapor Pressure: 1.4E-10mmHg at 25°C
• Boiling Point: 494.1°C at 760 mmHg
• Flash Point: 252.6°C
• PSA: 70.95000
• Density: 1.22g/cm³
• LogP: 0.50470
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 267.14705815
• Heavy Atom Count: 19
• Complexity: 276

Purity/Quality:

TETRAMINOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C2CC(C(CC2=C(C=C1)OC)O)NCCO
• Isomeric SMILES: COC1=C2C[C@@H]([C@H](CC2=C(C=C1)OC)O)NCCO

Technology Process of 5,8-Dimethoxy-2-(2-hydroxyethyl)amino-3-hydroxy-1,2,3,4-tetrahydronaphthalene

There total 3 articles about 5,8-Dimethoxy-2-(2-hydroxyethyl)amino-3-hydroxy-1,2,3,4-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5,8-dimethoxy-1,4-dihydronaphthalene (55077-79-7) → (2S,3S)-3-(2-Hydroxy-ethylamino)-5,8-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ol (64831-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-carboxy-peroxybenzoic acid / diethyl ether

2: ethanol

With 4-carboxy-peroxybenzoic acid; In diethyl ether; ethanol;

DOI:10.1002/ardp.19773100505

Reference yield:

p-benzoquinone (106-51-4) → (2S,3S)-3-(2-Hydroxy-ethylamino)-5,8-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ol (64831-69-2)

Guidance literature:

Multi-step reaction with 3 steps

1: (i), (ii) /BRN= 635994/

2: 4-carboxy-peroxybenzoic acid / diethyl ether

3: ethanol

With 4-carboxy-peroxybenzoic acid; In diethyl ether; ethanol;

DOI:10.1002/ardp.19773100505

Reference yield:

6,7-epoxy-5,6,7,8-tetrahydro-1,4-dimethoxynaphthalene (58851-64-2) + ethanolamine (141-43-5) → (2S,3S)-3-(2-Hydroxy-ethylamino)-5,8-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ol (64831-69-2)

Guidance literature:

In ethanol;

DOI:10.1002/ardp.19773100505

upstream raw materials:

6,7-epoxy-5,6,7,8-tetrahydro-1,4-dimethoxynaphthalene

ethanolamine

5,8-dimethoxy-1,4-dihydronaphthalene

p-benzoquinone