Pikromycin

Base Information

Chemical Name:Pikromycin
CAS No.:19721-56-3
Molecular Formula:C₂₈H₄₇NO₈
Molecular Weight:525.683
Hs Code.:
UNII:FBM8G3Z439
DSSTox Substance ID:DTXSID201026584
Metabolomics Workbench ID:21310
Wikidata:Q7193709
Wikipedia:Pikromycin
Mol file:19721-56-3.mol

Synonyms:picromycin;pikromycin

Suppliers and Price of Pikromycin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Pikromycin
1mg
$ 316.00

TRC
Pikromycin
5mg
$ 780.00

American Custom Chemicals Corporation
PICROMYCIN 95.00%
5MG
$ 519.46

Adipogen Life Sciences
Pikromycin ≥95%(HPLC)
5 mg
$ 240.00

Total 7 raw suppliers

Chemical Property of Pikromycin

Chemical Property:

Vapor Pressure:6.51E-22mmHg at 25°C
Melting Point:169.5℃
Boiling Point:688.1°Cat760mmHg
PKA:11.15±0.70(Predicted)
Flash Point:369.9°C
PSA：122.60000
Density:1.14g/cm³
LogP:2.51290
XLogP3:3.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:4
Exact Mass:525.33016746
Heavy Atom Count:37
Complexity:844

Purity/Quality:

98% ^*data from raw suppliers

Pikromycin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1C(C=CC(=O)C(CC(C(C(C(=O)C(C(=O)O1)C)C)OC2C(C(CC(O2)C)N(C)C)O)C)C)(C)O
Isomeric SMILES:CC[C@@H]1[C@@](/C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]2[C@@H]([C@H](C[C@H](O2)C)N(C)C)O)C)C)(C)O
Uses Pikromycin is an inhibitor of Prolyl endopeptidase.

Technology Process of Pikromycin

There total 13 articles about Pikromycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 77659-32-6
C₃₀H₄₉NO₉

: 19721-56-3
picromycin

Guidance literature:: With water; triethylamine; In methanol; at 20 ℃; for 3h;
DOI:10.1021/jo201158q

Reference yield:

: 6036-25-5,27656-75-3
narbomycin

: 19721-56-3
picromycin

Guidance literature:: With potassium dihydrogenphosphate; ethylenediaminetetraacetic acid; NADPH; Rate constant; Equilibrium constant;
DOI:10.1016/S0960-894X(98)00553-8

Reference yield:

: 1009036-47-8
(2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoic acid

: 19721-56-3
picromycin

Guidance literature:: Multi-step reaction with 10 steps

1.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 3 h / 20 °C

1.2: 15 h / 20 °C

2.1: 10-camphorsufonic acid / methanol / 1 h / 0 °C

3.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

4.1: tetrahydrofuran / 0.33 h / 20 °C

4.2: 20 °C

5.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

6.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 18 h / 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2.5 h / 20 °C

8.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

9.1: water; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 2 h / 0 °C

9.2: 13.25 h / -78 - 20 °C / Molecular sieve

10.1: water; triethylamine / methanol / 3 h / 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 2,4,6-trichlorobenzoyl chloride; 10-camphorsufonic acid; tetrabutyl ammonium fluoride; water; Dess-Martin periodane; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; dichloromethane; 1.1: Yamaguchi esterification / 1.2: Yamaguchi esterification / 4.1: Grignard reaction;
DOI:10.1021/jo201158q