(3S,4R)-3-hydroxy-3-methylhex-1-en-4-yl (2R,3S,4R,5S,6S,8R)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethyl-9-oxononanoate

Base Information

Chemical Name:(3S,4R)-3-hydroxy-3-methylhex-1-en-4-yl (2R,3S,4R,5S,6S,8R)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethyl-9-oxononanoate
CAS No.:1353285-70-7
Molecular Formula:C₃₄H₅₈O₇Si
Molecular Weight:606.916
Hs Code.:

Synonyms:(3S,4R)-3-hydroxy-3-methylhex-1-en-4-yl (2R,3S,4R,5S,6S,8R)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethyl-9-oxononanoate

Suppliers and Price of (3S,4R)-3-hydroxy-3-methylhex-1-en-4-yl (2R,3S,4R,5S,6S,8R)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethyl-9-oxononanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,4R)-3-hydroxy-3-methylhex-1-en-4-yl (2R,3S,4R,5S,6S,8R)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethyl-9-oxononanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4R)-3-hydroxy-3-methylhex-1-en-4-yl (2R,3S,4R,5S,6S,8R)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethyl-9-oxononanoate

There total 4 articles about (3S,4R)-3-hydroxy-3-methylhex-1-en-4-yl (2R,3S,4R,5S,6S,8R)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethyl-9-oxononanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1353285-68-3
(3S,4R)-3-hydroxy-3-methylhex-1-en-4-yl (2R,3S,4R,5S,6S,8R)-3-(tert-butyldimethylsilyloxy)-9-hydroxy-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoate

: 1353285-70-7
(3S,4R)-3-hydroxy-3-methylhex-1-en-4-yl (2R,3S,4R,5S,6S,8R)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethyl-9-oxononanoate

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jo201158q

Reference yield:

: 1198600-34-8
(3S,4R)-3-methylhex-1-ene-3,4-diol

: 1353285-70-7
(3S,4R)-3-hydroxy-3-methylhex-1-en-4-yl (2R,3S,4R,5S,6S,8R)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethyl-9-oxononanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 3 h / 20 °C

1.2: 15 h / 20 °C

2.1: 10-camphorsufonic acid / methanol / 1 h / 0 °C

3.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

With 2,4,6-trichlorobenzoyl chloride; 10-camphorsufonic acid; Dess-Martin periodane; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 1.1: Yamaguchi esterification / 1.2: Yamaguchi esterification;
DOI:10.1021/jo201158q

Reference yield:

: 1009036-47-8
(2R,3S,4R,5S,6S,8R)-3,9-di(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethylnonanoic acid

: 1353285-70-7
(3S,4R)-3-hydroxy-3-methylhex-1-en-4-yl (2R,3S,4R,5S,6S,8R)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-2,4,6,8-tetramethyl-9-oxononanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,4,6-trichlorobenzoyl chloride; triethylamine / tetrahydrofuran / 3 h / 20 °C

1.2: 15 h / 20 °C

2.1: 10-camphorsufonic acid / methanol / 1 h / 0 °C

3.1: Dess-Martin periodane / dichloromethane / 0.5 h / 20 °C

With 2,4,6-trichlorobenzoyl chloride; 10-camphorsufonic acid; Dess-Martin periodane; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 1.1: Yamaguchi esterification / 1.2: Yamaguchi esterification;
DOI:10.1021/jo201158q