2-(benzylamino)propane-1,3-diol

Base Information

• Chemical Name: 2-(benzylamino)propane-1,3-diol
• CAS No.: 124613-28-1
• Molecular Formula: C10H15NO2
• Molecular Weight: 181.235
• Mol file: 124613-28-1.mol

Synonyms:

Chemical Property of 2-(benzylamino)propane-1,3-diol

Chemical Property:

• Vapor Pressure: 7.51E-06mmHg at 25°C

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(benzylamino)propane-1,3-diol

There total 7 articles about 2-(benzylamino)propane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzaldehyde (100-52-7) + serinol (534-03-2) → 2-(benzylamino)propane-1,3-diol (124613-28-1)

Guidance literature:

With methanol; sodium tetrahydroborate; at 0 ℃; for 3h;

Reference yield:

C10H13NO2 (353263-64-6) → 2-(benzylamino)propane-1,3-diol (124613-28-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol202430e

Reference yield:

benzaldehyde (100-52-7) → 2-(benzylamino)propane-1,3-diol (124613-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: magnesium sulfate / methanol; dichloromethane / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; magnesium sulfate; In methanol; dichloromethane;

DOI:10.1021/ol202430e

upstream raw materials:

benzoyl-DL-serine

(RS)-N-benzylserine

C₁₀H₁₃NO₂

benzaldehyde

Downstream raw materials:

N-benzyl-N-(1,3-dihydroxypropan-2-yl)benzamide

4-methoxyphenyl benzyl-1,3-dihydroxypropan-2-yl-carbamate

1-benzyl-1-(1,3-dihydroxypropan-2-yl)-3-phenylurea

C₂₂H₄₃NO₂Si₂

Refernces

• 1、 -. "MODULATORS OF HEMOGLOBIN FOR THE TREATMENT OF SICKLE CELL DISEASE". Paragraph 0274. . Retrieved 2020/05/15.
• 2、 Uozumi, Yasuhiro,Tanahashi, Asako,Hayashi, Tamio. "Catalytic Asymmetric Construction of Morpholines and Piperazines by Palladium-Catalyzed Tandem Allylic Substitution Reactions". . p. 6826 - 6832. Retrieved 2007/10/02.