4-Acetamido-N-[2-(hydroxymethyl)-6-methylphenyl]benzamide

Base Information

Chemical Name:4-Acetamido-N-[2-(hydroxymethyl)-6-methylphenyl]benzamide
CAS No.:125558-43-2
Molecular Formula:C17H18N2O3
Molecular Weight:298.342
Hs Code.:
ChEMBL ID:CHEMBL277891
DSSTox Substance ID:DTXSID30564620
Nikkaji Number:J377.405H
Wikidata:Q82449388
Mol file:125558-43-2.mol

Synonyms:125558-43-2;4-Acetamido-N-[2-(hydroxymethyl)-6-methylphenyl]benzamide;CHEMBL277891;DTXSID30564620

Suppliers and Price of 4-Acetamido-N-[2-(hydroxymethyl)-6-methylphenyl]benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 4-Acetamido-N-[2-(hydroxymethyl)-6-methylphenyl]benzamide

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:298.13174244
Heavy Atom Count:22
Complexity:391

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=CC=C1)CO)NC(=O)C2=CC=C(C=C2)NC(=O)C

Technology Process of 4-Acetamido-N-[2-(hydroxymethyl)-6-methylphenyl]benzamide

There total 5 articles about 4-Acetamido-N-[2-(hydroxymethyl)-6-methylphenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.8%

: 108-24-7
acetic anhydride

: 131545-97-6
4-Amino-N-(2-hydroxymethyl-6-methyl-phenyl)-benzamide

: 125558-43-2
4-Acetylamino-N-(2-hydroxymethyl-6-methyl-phenyl)-benzamide

Guidance literature:: for 0.166667h; Ambient temperature;
DOI:10.1021/jm00108a003

Reference yield:

: 57772-50-6
2-amino-3-methylbenzyl alcohol

: 125558-43-2
4-Acetylamino-N-(2-hydroxymethyl-6-methyl-phenyl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 35 percent / triethylamine / tetrahydrofuran / Heating

2: 79.1 percent / NaOH / ethanol; tetrahydrofuran / 0.17 h / Ambient temperature

3: 82.2 percent / H₂ / 5percent Pt/Al₂O₃ / tetrahydrofuran / 3102.9 Torr

4: 62.8 percent / 0.17 h / Ambient temperature

With sodium hydroxide; hydrogen; triethylamine; Pt/Al₂O₃; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00108a003

Reference yield:

: 80866-76-8
2-methyl-6-hydroxymethyl-1-nitrobenzene

: 125558-43-2
4-Acetylamino-N-(2-hydroxymethyl-6-methyl-phenyl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 4 h / 3102.9 Torr

2: 35 percent / triethylamine / tetrahydrofuran / Heating

3: 79.1 percent / NaOH / ethanol; tetrahydrofuran / 0.17 h / Ambient temperature

4: 82.2 percent / H₂ / 5percent Pt/Al₂O₃ / tetrahydrofuran / 3102.9 Torr

5: 62.8 percent / 0.17 h / Ambient temperature

With sodium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; Pt/Al₂O₃; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00108a003