Benzamide, N-formyl- (7CI,8CI,9CI)

Base Information

• Chemical Name: Benzamide, N-formyl- (7CI,8CI,9CI)
• CAS No.: 4252-31-7
• Molecular Formula: C8H7NO2
• Molecular Weight: 149.149
• Hs Code.: 2924299090
• Mol file: 4252-31-7.mol

Synonyms:benzoyl-formyl-amine;Benzamide,N-formyl;Benzoyl-formyl-amin;1Q8;N-Benzoyl-formamid;N-formylbenzimide;Benzaminoformaldehyd;

Chemical Property of Benzamide, N-formyl- (7CI,8CI,9CI)

Chemical Property:

• Melting Point: 112-113 °C(Solv: ligroine (8032-32-4))
• Boiling Point: °Cat760mmHg
• PKA: 10.97±0.46(Predicted)
• Flash Point: °C
• PSA: 49.66000
• Density: 1.173g/cm³
• LogP: 1.41310

Purity/Quality:

99% ^*data from raw suppliers

N-Formylbenzamide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzamide, N-formyl- (7CI,8CI,9CI)

There total 64 articles about Benzamide, N-formyl- (7CI,8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-methylbenzamide (88070-48-8) → N-formylbenzamide (4252-31-7)

Guidance literature:

With potassium peroxymonosulfate sulfate; water; potassium bromide; In dichloromethane; at 40 ℃; for 12h; Sealed tube; Irradiation;

DOI:10.1055/s-0036-1591575

Reference yield: 94.0%

4-Dimethylamino-2-phenyl-1-oxa-3-azabuta-1,3-diene (121876-96-8) → N-formylbenzamide (4252-31-7)

Guidance literature:

With water; toluene-4-sulfonic acid; at 25 ℃; for 1h; Reagent/catalyst; Temperature; Inert atmosphere; Green chemistry;

DOI:10.1039/d0ob01080d

Reference yield: 92.0%

N-benzylformamide (6343-54-0) → N-formylbenzamide (4252-31-7)

Guidance literature:

With acetic anhydride; periodic acid; chromium(VI) oxide; In acetonitrile; at 0 ℃; for 1h;

DOI:10.1039/b404823g

upstream raw materials:

N-(hydroxymethyl)benzamide

N,N-bis(trimethylsilyl)formamide

benzoyl chloride

Hippuric Acid

Downstream raw materials:

1-phenyl-5-phenyl-1H-1,2,4-triazole

1-Benzoyl-4,5-dihydro-1H-pyrrol-3-carbonsaeure-ethylester

(Z)-3-benzoylamino-acrylic acid ethyl ester

(2E,4Z)-methyl 5-benzamidopenta-2,4-dienoate

Refernces

• 1、 Finkbeiner,H.. "-". . p. 2861 - 2862. Retrieved 1965.
• 2、 Sreejyothi,Bhattacharyya, Kalishankar,Kumar, Shiv,Kumar Hota, Pradip,Datta, Ayan,Mandal, Swadhin K.. "An NHC-Stabilised Phosphinidene for Catalytic Formylation: A DFT-Guided Approach". supporting information. p. 11656 - 11662. Retrieved 2021/07/02.
• 3、 Huang, Hsin-Yi,Liang, Chien-Fu,Lin, Xiu-Yi,Yen, Shih-Yao. "Facile access to: N-formyl imide as an N-formylating agent for the direct synthesis of N-formamides, benzimidazoles and quinazolinones". supporting information. p. 5726 - 5733. Retrieved 2020/08/21.