Ethanone, 1,2-bis(2-fluorophenyl)-2-hydroxy-

Base Information

• Chemical Name: Ethanone, 1,2-bis(2-fluorophenyl)-2-hydroxy-
• CAS No.: 125652-30-4
• Molecular Formula: C14H10F2O2
• Molecular Weight: 248.229
• Mol file: 125652-30-4.mol

Synonyms:

Chemical Property of Ethanone, 1,2-bis(2-fluorophenyl)-2-hydroxy-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1,2-bis(2-fluorophenyl)-2-hydroxy-

There total 7 articles about Ethanone, 1,2-bis(2-fluorophenyl)-2-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1,2-bis(2-fluorophenyl)ethane-1,2-dione (573-43-3) → 1,2-bis(2-fluorophenyl)-2-hydroxyethan-1-one (125652-30-4)

Guidance literature:

With water; zinc trifluoromethanesulfonate; zinc; In 1,4-dioxane; at 90 ℃; for 1h; Inert atmosphere; Schlenk technique; Green chemistry;

DOI:10.1039/d1ob00155h

Reference yield: 86.0%

2-Fluorobenzaldehyde (446-52-6) → 1,2-bis(2-fluorophenyl)-2-hydroxyethan-1-one (125652-30-4)

Guidance literature:

With Thiamine hydrochloride; sodium hydroxide; In ethanol; at 55 ℃; for 16h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201706261

Reference yield: 78.0%

2-Fluorobenzaldehyde (446-52-6) + isobutyraldehyde (78-84-2) → 1-(2-fluorophenyl)-1-hydroxy-3-methylbutan-2-one (1568852-94-7) + 1,2-bis(2-fluorophenyl)-2-hydroxyethan-1-one (125652-30-4)

Guidance literature:

With 2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; caesium carbonate; In m-xylene; at 20 ℃; for 24h; chemoselective reaction; Inert atmosphere;

DOI:10.1039/c3ob42486c

upstream raw materials:

2-Fluorobenzaldehyde

2-methyl-3-phenyl-2-propenal

3-phenyl-propenal

3-phenyl-propionaldehyde

Downstream raw materials:

2,2'-difluorobenzilic acid

5,5-bis-(2-fluorophenyl)-hydantoin

2,3-bis-(2-fluorophenyl)quinoxaline

1-ethyl-4,5-bis(2-fluorophenyl)-1H-imidazole

Refernces

• 1、 Wang, Guangcheng,Wang, Jing,He, Dianxiong,Li, Xin,Li, Juan,Peng, Zhiyun. "Synthesis and biological evaluation of novel 1,2,4-triazine derivatives bearing carbazole moiety as potent α-glucosidase inhibitors". . p. 2806 - 2809. Retrieved 2016.
• 2、 Liu, Wei,Zhao, Liang-Liang,Melaimi, Mohand,Cao, Lei,Xu, Xingyu,Bouffard, Jean,Bertrand, Guy,Yan, Xiaoyu. "Mesoionic Carbene (MIC)-Catalyzed H/D Exchange at Formyl Groups". supporting information. p. 2484 - 2494. Retrieved 2019/09/10.
• 3、 -. "COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCERS AND OTHER MEDICAL CONDITIONS". Paragraph 0101; 0103; 0109; 00128. . Retrieved 2017/02/09.