5-{[4-(3-Phenylpropanoyl)phenyl]methyl}-1,3-thiazolidine-2,4-dione

Base Information

Chemical Name:5-{[4-(3-Phenylpropanoyl)phenyl]methyl}-1,3-thiazolidine-2,4-dione
CAS No.:125734-22-7
Molecular Formula:C19H17NO3S
Molecular Weight:339.415
Hs Code.:
ChEMBL ID:CHEMBL54669
DSSTox Substance ID:DTXSID50560609
Nikkaji Number:J474.833F
Mol file:125734-22-7.mol

Synonyms:125734-22-7;CHEMBL54669;SCHEMBL9377291;DTXSID50560609;KMRWVKUAYIEHSE-UHFFFAOYSA-N;5-{[4-(3-Phenylpropanoyl)phenyl]methyl}-1,3-thiazolidine-2,4-dione;5-[4-(3-Phenylpropionyl)benzyl]thiazolidine-2,4-dione

Suppliers and Price of 5-{[4-(3-Phenylpropanoyl)phenyl]methyl}-1,3-thiazolidine-2,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 5-{[4-(3-Phenylpropanoyl)phenyl]methyl}-1,3-thiazolidine-2,4-dione

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:339.09291458
Heavy Atom Count:24
Complexity:479

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)CCC(=O)C2=CC=C(C=C2)CC3C(=O)NC(=O)S3

Technology Process of 5-{[4-(3-Phenylpropanoyl)phenyl]methyl}-1,3-thiazolidine-2,4-dione

There total 4 articles about 5-{[4-(3-Phenylpropanoyl)phenyl]methyl}-1,3-thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 125734-14-7
(E)-5-<4-(3-phenyl-2-propenoyl)benzyl>thiazolidine-2,4-dione

: 125734-22-7
5-<4-(3-phenylpropionyl)benzyl>thiazolidine-2,4-dione

Guidance literature:: With triethylsilane; In trifluoroacetic acid; at 0 ℃; for 0.416667h;
DOI:10.1021/jm00088a022

Reference yield:

: 18910-19-5
4-acetyl-alpha-bromobenzenepropanoic acid

: 125734-22-7
5-<4-(3-phenylpropionyl)benzyl>thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sulfolane, 2.) HCl / 1.) 110 deg C, 5 h, 2.) 110 deg C, overnight

2: 24 percent / sodium methoxide / ethanol / 1.5 h / Heating

3: 82 percent / triethylsilane / trifluoroacetic acid / 0.42 h / 0 °C

With sulfolane; hydrogenchloride; triethylsilane; sodium methylate; In ethanol; trifluoroacetic acid;
DOI:10.1021/jm00088a022

Reference yield:

: 100-52-7
benzaldehyde

: 125734-22-7
5-<4-(3-phenylpropionyl)benzyl>thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 24 percent / sodium methoxide / ethanol / 1.5 h / Heating

2: 82 percent / triethylsilane / trifluoroacetic acid / 0.42 h / 0 °C

With triethylsilane; sodium methylate; In ethanol; trifluoroacetic acid;
DOI:10.1021/jm00088a022