(2E)-1-(4-aminophenyl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one

Base Information

• Chemical Name: (2E)-1-(4-aminophenyl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one
• CAS No.: 126443-09-2
• Molecular Formula: C17H18N2O
• Molecular Weight: 266.343
• Mol file: 126443-09-2.mol

Synonyms:1-(4-aminophenyl)-3-(4-(dimethylamino)phenyl)-2-propen-1-one;(E)-4-(dimethylamino)-4'-aminochalcone;(E)-1-(4-aminophenyl)-3-(4-(dimethylamino) phenyl)prop-2-en-1-one;(E)-1-(4-Amino-phenyl)-3-(4-dimethylamino-phenyl)-propenone;(E)-1-(4-aminophenyl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one;(E)-1-(4-aminophenyl)-3-(4-(dimethylamino)phenyl)prop-2-en-1-one;

Chemical Property of (2E)-1-(4-aminophenyl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one

Chemical Property:

• PSA: 46.33000
• LogP: 3.81210

Purity/Quality:

98%min ^*data from raw suppliers

(2E)-1-(4-Aminophenyl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E)-1-(4-aminophenyl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one

There total 4 articles about (2E)-1-(4-aminophenyl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

p-aminobenzophenone (99-92-3) + 4-dimethylamino-benzaldehyde (100-10-7) → 1-(4-aminophenyl)-3-<4-(dimethylamino)phenyl>prop-2-en-1-one (126443-09-2)

Guidance literature:

With sodium hydroxide; In ethanol; Microwave irradiation;

DOI:10.1016/j.bioorg.2019.103527

Reference yield:

N-(4-Hydroxybenzyliden)-4-acetylanilin (114569-19-6) + 4-dimethylamino-benzaldehyde (100-10-7) → 1-(4-aminophenyl)-3-<4-(dimethylamino)phenyl>prop-2-en-1-one (126443-09-2)

Guidance literature:

N-(4-Hydroxybenzyliden)-4-acetylanilin; With sodium methylate; Merrifield resin; In N,N-dimethyl-formamide; for 0.166667h; microwave irradiation;

4-dimethylamino-benzaldehyde; With piperidine; In N,N-dimethyl-formamide; for 0.25h; microwave irradiation;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

(E)-3-(4-(N,N-dimethylamino)phenyl)-1-(4-nitrophenyl)prop-2-en-1-one (1161-23-5,20431-58-7) → 1-(4-aminophenyl)-3-<4-(dimethylamino)phenyl>prop-2-en-1-one (126443-09-2)

Guidance literature:

With hydrogenchloride; iron; In ethanol; water; for 4h; Reflux;

DOI:10.1016/j.bmcl.2009.02.038

upstream raw materials:

p-aminobenzophenone

4-dimethylamino-benzaldehyde

N-(4-Hydroxybenzyliden)-4-acetylanilin

(E)-3-(4-(N,N-dimethylamino)phenyl)-1-(4-nitrophenyl)prop-2-en-1-one

Downstream raw materials:

2-bromo-N-(4-((E)-3-(4-(dimethylamino)phenyl)acryloyl)phenyl)acrylamide

N-(4′-[(2E)-3-(4-dimethylaminophenyl)-1-(phenyl)prop-2-en-1-one])acetamide