1H-Indazole-3-carboxylic acid, 1-ethyl-

Base Information

• Chemical Name: 1H-Indazole-3-carboxylic acid, 1-ethyl-
• CAS No.: 127472-41-7
• Molecular Formula: C10H10N2O2
• Molecular Weight: 190.19900
• Mol file: 127472-41-7.mol

Synonyms:1H-Indene,1-ethyl-2,3-dihydro;1-ETHYLINDAN;1-ethylindazole-3-carboxylic acid;1-Aethyl-1H-indazol-3-carbonsaeure;1-Ethylindane;Indan,1-ethyl;ethyl indazole-3-carboxylic acid;1-Ethyl-[2,3-dihydroindene];ethyl indan;1-Aethyl-indan;

Chemical Property of 1H-Indazole-3-carboxylic acid, 1-ethyl-

Chemical Property:

• PSA: 55.12000
• LogP: 1.75440

Purity/Quality:

97% ^*data from raw suppliers

1-Ethyl-1H-indazole-3-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indazole-3-carboxylic acid, 1-ethyl-

There total 6 articles about 1H-Indazole-3-carboxylic acid, 1-ethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 1-ethyl-1H-indazole-3-carboxylate (173599-97-8) → 1-ethyl-1H-indazole-3-carboxylic acid (127472-41-7)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; for 20h; Ambient temperature;

DOI:10.1248/cpb.43.1912

Reference yield:

methyl 1H-indazole-3-carboxylate (43120-28-1) → 1-ethyl-1H-indazole-3-carboxylic acid (127472-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) tert-BuOK / 1.) THF, 5 deg C, 1 h, 2.) THF, RT, 20 h

2: 97 percent / 1 N aq. NaOH / tetrahydrofuran / 20 h / Ambient temperature

With sodium hydroxide; potassium tert-butylate; In tetrahydrofuran;

DOI:10.1248/cpb.43.1912

Reference yield:

1H-Indazole-3-carboxylic acid (4498-67-3) → 1-ethyl-1H-indazole-3-carboxylic acid (127472-41-7)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 3 h / Reflux

2: N,N-dimethyl-formamide / 2 h / 60 °C

3: sodium hydroxide / tetrahydrofuran / 18 h / 20 °C

With thionyl chloride; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201700446

upstream raw materials:

methyl 1-ethyl-1H-indazole-3-carboxylate

ethyl iodide

ethyl 1H-indazole-3-carboxylate

methyl 1H-indazole-3-carboxylate

Downstream raw materials:

N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1-ethyl-1H-indazole-3-carboxamide

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