2'-Amino-2-chloro-5'-fluoroacetophenone

Base Information

Chemical Name:2'-Amino-2-chloro-5'-fluoroacetophenone
CAS No.:128076-64-2
Molecular Formula:C8H7ClFNO
Molecular Weight:187.59900
Hs Code.:
DSSTox Substance ID:DTXSID20444321
Wikidata:Q82262437
Mol file:128076-64-2.mol

Synonyms:128076-64-2;2'-amino-2-chloro-5'-fluoroacetophenone;SCHEMBL5795078;DTXSID20444321;IZAPRVJOMNGPLC-UHFFFAOYSA-N;1-(2-Amino-5-fluorophenyl)-2-chloroethan-1-one

Suppliers and Price of 2'-Amino-2-chloro-5'-fluoroacetophenone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 2'-Amino-2-chloro-5'-fluoroacetophenone

Chemical Property:

PSA：43.09000
LogP:2.41060
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:187.0200197
Heavy Atom Count:12
Complexity:176

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1F)C(=O)CCl)N

Technology Process of 2'-Amino-2-chloro-5'-fluoroacetophenone

There total 4 articles about 2'-Amino-2-chloro-5'-fluoroacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107-14-2
chloroacetonitrile

: 371-40-4
4-fluoroaniline

: 128076-64-2
2'-amino-2-chloro-5'-fluoroacetophenone

Guidance literature:: With aluminium trichloride; boron trichloride; Yield given. Multistep reaction; 1.) dichloromethane, benzene, 5 - 10 deg C, 2.) dichloromethane, benzene, reflux, 20 h;
DOI:10.1016/S0223-5234(96)80002-X

Reference yield:

: 371-40-4
4-fluoroaniline

: 128076-64-2
2'-amino-2-chloro-5'-fluoroacetophenone

Guidance literature:: Multi-step reaction with 2 steps

1.1: boron trichloride / dichloromethane / 3 h / 0 °C / Inert atmosphere

1.2: 6 h / 0 °C / Reflux; Inert atmosphere

2.1: hydrogenchloride; water / dichloromethane / Reflux; Inert atmosphere

With hydrogenchloride; water; boron trichloride; In dichloromethane;
DOI:10.1002/adsc.201701028