2-Chloro-7-methoxyquinoline-3-carbonitrile

Base Information

• Chemical Name: 2-Chloro-7-methoxyquinoline-3-carbonitrile
• CAS No.: 128259-63-2
• Molecular Formula: C11H7ClN2O
• Molecular Weight: 218.642
• Hs Code.: 2933499090
• European Community (EC) Number: 802-745-4
• DSSTox Substance ID: DTXSID10354662
• Wikidata: Q82132943
• ChEMBL ID: CHEMBL1894733
• Mol file: 128259-63-2.mol

Synonyms:2-chloro-7-methoxyquinoline-3-carbonitrile;128259-63-2;2-Chloro-7-methoxy-3-quinolinecarbonitrile;2-Chloro-7-methoxy-quinoline-3-carbonitrile;MFCD02232018;ChemDiv3_007627;MLS000687322;SCHEMBL8524163;CHEMBL1894733;DTXSID10354662;UTLRIOWIEJHVQJ-UHFFFAOYSA-N;HMS1494K15;HMS2643J07;CCG-26239;AKOS000589448;AB11603;IDI1_025537;chloro-7-methoxy-3-quinolinecarbonitrile;AM807502;SMR000285080;CS-0334572;EU-0054220;FT-0759931;A849248;EN300-23939788;J-005584;BRD-K30337148-001-01-6;2-Chloro-7-methoxyquinoline-3-carbonitrile, AldrichCPR

Chemical Property of 2-Chloro-7-methoxyquinoline-3-carbonitrile

Chemical Property:

• Vapor Pressure: 1.71E-06mmHg at 25°C
• Boiling Point: 396.5oC at 760 mmHg
• Flash Point: 193.6oC
• PSA: 45.91000
• Density: 1.36g/cm3
• LogP: 2.76848
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 218.0246905
• Heavy Atom Count: 15
• Complexity: 275

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-7-methoxyquinoline-3-carbonitrile ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=NC(=C(C=C2C=C1)C#N)Cl

Technology Process of 2-Chloro-7-methoxyquinoline-3-carbonitrile

There total 7 articles about 2-Chloro-7-methoxyquinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-chloro-7-methoxyquinoline-3-carbaldehyde (68236-20-4) → 2-chloro-7-methoxy-3-quinolinecarbonitrile (128259-63-2)

Guidance literature:

With ammonia; iodine; In tetrahydrofuran; water; at 20 ℃; for 1.41667h;

Reference yield: 79.0%

2-Chloro-7-methoxy-quinoline-3-carbaldehyde oxime → 2-chloro-7-methoxy-3-quinolinecarbonitrile (128259-63-2)

Guidance literature:

With acetic anhydride; for 3h; Heating;

Reference yield: 77.0%

(E)-2-Cyano-3-dimethylamino-N-(3-methoxy-phenyl)-acrylamide (128259-57-4) → 2-chloro-7-methoxy-3-quinolinecarbonitrile (128259-63-2)

Guidance literature:

With trichlorophosphate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; for 20h; Ambient temperature;

upstream raw materials:

(E)-2-Cyano-3-dimethylamino-N-(3-methoxy-phenyl)-acrylamide

2-chloro-7-methoxyquinoline-3-carbaldehyde

m-Anisidine

m-methoxyacetanilide

Downstream raw materials:

1-benzyl-8-methoxy-1H-pyrimido[4,5-b]quinolin-4-one

2-(benzylamino)-7-methoxyquinoline-3-carbonitrile

7-methoxy-2-phenylethynyl-quinoline-3-carbonitrile

(E)-1-(3-Amino-7-methoxy-thieno[2,3-b]quinolin-2-yl)-3-(4-methoxy-phenyl)-propenone

Refernces

• 1、 Upadhyay, Shraddha,Chandra, Atish,Singh, Seema,Singh, Radhey M.. "An alternate route to the synthesis of imidazo[1,2-a]quinolines using I2-NaI reagent". scheme or table. p. 1202 - 1205. Retrieved 2011/11/04.
• 2、 Upadhyay, Shraddha,Chandra, Atish,Singh, Radhey M.. "A one pot method of conversion of aldehydes into nitriles using iodine in ammonia water: Synthesis of 2-chloro-3-cyanoquinolines". experimental part. p. 152 - 154. Retrieved 2009/12/03.