(E)-2-CYANO-3-(DIMETHYLAMINO)-N-(3-METHOXYPHENYL)-2-PROPENAMIDE

Base Information

• Chemical Name: (E)-2-CYANO-3-(DIMETHYLAMINO)-N-(3-METHOXYPHENYL)-2-PROPENAMIDE
• CAS No.: 128259-57-4
• Molecular Formula: C₁₃H₁₅N₃O₂
• Molecular Weight: 245.281
• Mol file: 128259-57-4.mol

Synonyms:(E)-2-Cyano-3-dimethylamino-N-(3-methoxy-phenyl)-acrylamide

Chemical Property of (E)-2-CYANO-3-(DIMETHYLAMINO)-N-(3-METHOXYPHENYL)-2-PROPENAMIDE

Chemical Property:

Purity/Quality:

(E)-2-Cyano-3-(dimethylamino)-N-(3-methoxyphenyl)-2-propenamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-CYANO-3-(DIMETHYLAMINO)-N-(3-METHOXYPHENYL)-2-PROPENAMIDE

There total 1 articles about (E)-2-CYANO-3-(DIMETHYLAMINO)-N-(3-METHOXYPHENYL)-2-PROPENAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-cyano-N-(3-methoxyphenyl)acetamide (91818-29-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → (E)-2-Cyano-3-dimethylamino-N-(3-methoxy-phenyl)-acrylamide (128259-57-4)

Guidance literature:

With toluene-4-sulfonic acid; orthoformic acid triethyl ester; at 120 ℃; for 20h;

Reference yield: 77.0%

(E)-2-Cyano-3-dimethylamino-N-(3-methoxy-phenyl)-acrylamide (128259-57-4) → 2-chloro-7-methoxy-3-quinolinecarbonitrile (128259-63-2)

Guidance literature:

With trichlorophosphate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; for 20h; Ambient temperature;

upstream raw materials:

2-cyano-N-(3-methoxyphenyl)acetamide

N,N-dimethyl-formamide

Downstream raw materials:

2-chloro-7-methoxy-3-quinolinecarbonitrile