alpha-Cyano-3-fluorocinnamamide

Base Information

Chemical Name:alpha-Cyano-3-fluorocinnamamide
CAS No.:129115-54-4
Molecular Formula:C10H7FN2O
Molecular Weight:190.177
Hs Code.:
European Community (EC) Number:651-456-8
Nikkaji Number:J709.359D,J936.990B
ChEMBL ID:CHEMBL1927351

Synonyms:2-cyano-3-(3-fluorophenyl)prop-2-enamide;(E)-2-cyano-3-(4-fluorophenyl)prop-2-enamide;alpha-Cyano-3-fluorocinnamamide;2-CYANO-3-(4-FLUORO-PHENYL)-ACRYLAMIDE;CINNAMAMIDE, alpha-CYANO-3-FLUORO-;2-(3-Fluorobenzylidene)-2-cyanoacetamide;Acrylamide, 2-cyano-3-(m-fluorophenyl)-;2-Propenamide, 2-cyano-3-(3-fluorophenyl)-;CHEMBL1927351;AKOS003246293;(e)-2-cyano-3-(4-fluorophenyl)acrylamide

Suppliers and Price of alpha-Cyano-3-fluorocinnamamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of alpha-Cyano-3-fluorocinnamamide

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:190.05424101
Heavy Atom Count:14
Complexity:295

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C=C(C#N)C(=O)N)F
Isomeric SMILES:C1=CC(=CC=C1/C=C(\C#N)/C(=O)N)F

Technology Process of alpha-Cyano-3-fluorocinnamamide

There total 4 articles about alpha-Cyano-3-fluorocinnamamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 107-91-5
cyanoacetic acid amide

: 129115-54-4
2-cyano-3-(4-fluorophenyl)acrylamide

Guidance literature:: With sodium hydroxide; In methanol; at 40 ℃;
DOI:10.1021/acs.joc.5b02226

Reference yield:

: 1352994-22-9
5-amino-3-(4-fluorophenyl)-2,3-dihydroisoxazole-4-carbonitrile

: 129115-54-4
2-cyano-3-(4-fluorophenyl)acrylamide

Guidance literature:: 5-amino-3-(4-fluorophenyl)-2,3-dihydroisoxazole-4-carbonitrile; With hydrogenchloride; In water; at 20 ℃; for 0.5h; pH=1 - 3;

In water; chemoselective reaction;
DOI:10.1039/c1ob06318a

Reference yield:

: 2826-22-4
4-fluorobenzylidenemalononitrile

: 129115-54-4
2-cyano-3-(4-fluorophenyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium hydroxide / water / 4 h / 20 °C / pH 9 - 10

2: hydrogenchloride / water / 0.5 h / 20 °C / pH 1 - 3

With hydrogenchloride; hydroxylamine hydrochloride; sodium hydroxide; In water;
DOI:10.1039/c1ob06318a