2-(4-FLUOROBENZYLIDENE)-MALONONITRILE

Base Information

• Chemical Name: 2-(4-FLUOROBENZYLIDENE)-MALONONITRILE
• CAS No.: 2826-22-4
• Molecular Formula: C10H5FN2
• Molecular Weight: 172.162
• Hs Code.: 2926909090
• Mol file: 2826-22-4.mol

Synonyms:[(4-fluorophenyl)methylene]methane-1,1-dicarbonitrile;2-(4-fluorophenylmethylene)malononitrile;2-(4-fluorobenzylidene)malononitrile;2(4-fluorophenylmethylidene)malononitrile;(4-fluorobenzylidene)propanedinitrile;para-fluorophenylmethylene-malononitrile;p-fluorobenzylidenemalononitrile;4-Fluorobenzalmalononitrile;

Chemical Property of 2-(4-FLUOROBENZYLIDENE)-MALONONITRILE

Chemical Property:

• Melting Point: 126.8-127.2 °C
• Boiling Point: 293.4±25.0 °C(Predicted)
• PSA: 47.58000
• Density: 1.250±0.06 g/cm3(Predicted)
• LogP: 2.25626

Purity/Quality:

95% ^*data from raw suppliers

(4-fluorobenzylidene)propanedinitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-FLUOROBENZYLIDENE)-MALONONITRILE

There total 10 articles about 2-(4-FLUOROBENZYLIDENE)-MALONONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-fluorobenzaldehyde (459-57-4) + malononitrile (109-77-3) → 4-fluorobenzylidenemalononitrile (2826-22-4)

Guidance literature:

With 1-(3-silica-supported propyl)-3-[(3-{[1-(3-silica-supported propyl)-4,5-dihydro-1H-imidazol-3-ium-3-yl]methyl}-2,4,6-trimethylphenyl)methyl]-4,5-dihydro-1H-imidazol-3-ium chloride; at 100 ℃; for 4h;

DOI:10.1039/b916767f

Reference yield: 89.0%

4-fluorobenzaldehyde (459-57-4) + ethenetetracarbonitrile (670-54-2) → 4-fluorobenzylidenemalononitrile (2826-22-4)

Guidance literature:

With cycl-isopropylidene malonate; water; at 80 ℃; for 1.5h;

DOI:10.1248/cpb.56.1480

Reference yield: 68.0%

4-fluorobenzaldehyde (459-57-4) + acetophenone (98-86-2) + malononitrile (109-77-3) → 4-fluorobenzylidenemalononitrile (2826-22-4) + 5'-amino-4-fluoro-[1,1':3',1''-terphenyl]-4',6'-dicarbonitrile (77198-48-2) + 4-fluorochalcone (1608-51-1,22966-07-0,102692-46-6)

Guidance literature:

With potassium carbonate; at 60 ℃; for 0.1h; neat (no solvent);

DOI:10.1007/s00706-010-0302-8

upstream raw materials:

4-fluorobenzaldehyde

malononitrile

4-fluorobenzalaniline

ethenetetracarbonitrile

Downstream raw materials:

N-methylmorpholinium 6-amino-4-(4-fluorophenyl)-3,5-dicyano-2-pyridinethiolate

4-(4-fluorophenyl)-2-thioxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile

2-Amino-4-(4-fluoro-phenyl)-1,5-dithia-spiro[5.5]undec-2-ene-3-carbonitrile

3-(4-fluorophenyl-3-oxo-1-(2-thienyl)propyl)propanedinitrile