Pentanoic acid, 4,5-dihydroxy-, ethyl ester, (4S)-

Base Information

Chemical Name:Pentanoic acid, 4,5-dihydroxy-, ethyl ester, (4S)-
CAS No.:130202-83-4
Molecular Formula:C7H14O4
Molecular Weight:162.186
Hs Code.:

Synonyms:

Suppliers and Price of Pentanoic acid, 4,5-dihydroxy-, ethyl ester, (4S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Pentanoic acid, 4,5-dihydroxy-, ethyl ester, (4S)-

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Pentanoic acid, 4,5-dihydroxy-, ethyl ester, (4S)-

There total 1 articles about Pentanoic acid, 4,5-dihydroxy-, ethyl ester, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 5336-08-3
D-Ribono-1,4-lactone

: 32780-06-6
(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran

: 130202-83-4
ethyl (S)-4,5-dihydroxypentanoate

Guidance literature:: With potassium perrhenate; phosphoric acid; palladium 10% on activated carbon; hydrogen; pyrographite; at 150 ℃; for 18h; under 3750.38 Torr; Autoclave;
DOI:10.1021/jacs.7b07801

Reference yield:

: 130202-83-4
ethyl (S)-4,5-dihydroxypentanoate

: C₂₂H₃₁NO₃S₃

Guidance literature:: Multi-step reaction with 16 steps

1.1: 6.16 g / imidazole; 4-(dimethylamino)pyridine / CH₂Cl₂

2.1: 98 percent / DIBAL-H / tetrahydrofuran; hexane / 1 h / -78 °C

3.1: BF₃*OEt₂ / tetrahydrofuran; hexane / 3.33 h

3.2: 1.6 g / H₂O₂; NaOH / tetrahydrofuran; hexane; H₂O / 1 h / Heating

4.1: imidazole; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 h / 20 °C

5.1: CSA / CH₂Cl₂; methanol / 4 h / 20 °C

6.1: 99 percent / NaH; N-(2,4,6-triisopropylbenzenesulfonyl)imidazole / tetrahydrofuran / 0 - 20 °C

7.1: t-BuLi / diethyl ether / 1 h / -78 - -45 °C

7.2: diethyl ether / 2 h / -78 - -20 °C

7.3: 60 mg / tetrahydrofuran; 1,2-dimethoxy-ethane / 2 h / -78 - 0 °C

8.1: 98 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 °C

9.1: triethylamine / tetrahydrofuran / 0 - 20 °C

10.1: K₂CO₃ / methanol / 12 h / 20 °C

11.1: 0.634 g / Na-Hg; Na₂HPO₄ / methanol / 32 h

12.1: 83 percent / HCl / acetone / 24 h

13.1: LiHMDS / tetrahydrofuran / 2 h / -78 °C

14.1: 0.047 g / second generation Grubbs catalyst / benzene / 65 °C

15.1: 96 percent / NaBH₄ / methanol / 0.5 h / 0 °C

16.1: 86 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 - 20 °C

With 1H-imidazole; hydrogenchloride; dmap; sodium tetrahydroborate; disodium hydrogenphosphate; sodium amalgam; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; tert.-butyl lithium; sodium hydride; diisobutylaluminium hydride; potassium carbonate; triethylamine; lithium hexamethyldisilazane; 1-[(2,4,6-triisopropylphenyl)sulfonyl]-1H-imidazole; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; acetone; benzene;
DOI:10.1021/jo052314g

Reference yield:

: 130202-83-4
ethyl (S)-4,5-dihydroxypentanoate

: tert-butyl-[2-methyl-1-(2-oxiranyl-ethyl)-but-3-enyloxy]-diphenyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1.1: 6.16 g / imidazole; 4-(dimethylamino)pyridine / CH₂Cl₂

2.1: 98 percent / DIBAL-H / tetrahydrofuran; hexane / 1 h / -78 °C

3.1: BF₃*OEt₂ / tetrahydrofuran; hexane / 3.33 h

3.2: 1.6 g / H₂O₂; NaOH / tetrahydrofuran; hexane; H₂O / 1 h / Heating

4.1: imidazole; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 h / 20 °C

5.1: CSA / CH₂Cl₂; methanol / 4 h / 20 °C

6.1: 99 percent / NaH; N-(2,4,6-triisopropylbenzenesulfonyl)imidazole / tetrahydrofuran / 0 - 20 °C

With 1H-imidazole; dmap; camphor-10-sulfonic acid; boron trifluoride diethyl etherate; sodium hydride; diisobutylaluminium hydride; 1-[(2,4,6-triisopropylphenyl)sulfonyl]-1H-imidazole; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jo052314g