4H-1,3-Dioxin-4-one, 2,2-dimethyl-6-(2-oxopropyl)-

Base Information

• Chemical Name: 4H-1,3-Dioxin-4-one, 2,2-dimethyl-6-(2-oxopropyl)-
• CAS No.: 130473-38-0
• Molecular Formula: C9H12O4
• Molecular Weight: 184.192
• Mol file: 130473-38-0.mol

Synonyms:2,2-Dimethyl-6-(2-oxopropyl)-1,3-dioxin-4-one;

Chemical Property of 4H-1,3-Dioxin-4-one, 2,2-dimethyl-6-(2-oxopropyl)-

Chemical Property:

• Melting Point: 57-58 °C(Solv: hexane (110-54-3); toluene (108-88-3))
• Boiling Point: 303.5±42.0 °C(Predicted)
• PSA: 52.60000
• Density: 1.109±0.06 g/cm3(Predicted)
• LogP: 1.15890

Purity/Quality:

99%, ^*data from raw suppliers

2,2-Dimethyl-6-(2-oxo-propyl)-[1,3]dioxin-4-one 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2,2-Dimethyl-6-(2-oxopropyl)-4H-1,3-dioxin-4-one, is a building block used in various chemical synthesis. It is used in the preparation of methylideneoxanone compounds and substituted derivatives as inhibitors of telomerase.

Technology Process of 4H-1,3-Dioxin-4-one, 2,2-dimethyl-6-(2-oxopropyl)-

There total 3 articles about 4H-1,3-Dioxin-4-one, 2,2-dimethyl-6-(2-oxopropyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

6-(2-hydroxypropyl)-2,2-dimethyl-4H-1,3-dioxin-4-one (136801-79-1) → 2,2-dimethyl-6-(2-oxo-2-methylethyl)-4H-1,3-dioxin-4-one (130473-38-0)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.3390/molecules24173193

Reference yield: 70.0%

N-Acetylimidazole (2466-76-4) + 2,2,6-trimethyl-4H-1,3-dioxin-4-one (5394-63-8) → 2,2-dimethyl-6-(2-oxo-2-methylethyl)-4H-1,3-dioxin-4-one (130473-38-0)

Guidance literature:

2,2,6-trimethyl-4H-1,3-dioxin-4-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -20 ℃; for 0.75h; Inert atmosphere;

With diethylzinc; In tetrahydrofuran; hexane; at -20 ℃; for 2.5h; Inert atmosphere;

N-Acetylimidazole; Further stages;

DOI:10.1021/jo2009356

Reference yield: 55.0%

2,2,6-trimethyl-4H-1,3-dioxin-4-one (5394-63-8) + acetyl chloride (75-36-5) → 2,2-dimethyl-6-(2-oxo-2-methylethyl)-4H-1,3-dioxin-4-one (130473-38-0)

Guidance literature:

2,2,6-trimethyl-4H-1,3-dioxin-4-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -70 ℃; for 0.833333h;

acetyl chloride; In tetrahydrofuran; at -70 ℃; for 0.5h;

DOI:10.1021/ol901979x

upstream raw materials:

2,2,6-trimethyl-4H-1,3-dioxin-4-one

acetyl chloride

N-Acetylimidazole

6-(2-hydroxypropyl)-2,2-dimethyl-4H-1,3-dioxin-4-one

Downstream raw materials:

4-[(4-methoxyphenyl)amino]-6-methyl-2H-pyran-2-one

2,3-Dihydro-2,7-dimethyl-4H,5H-pyrano-<4,3-b>-pyran-4,5-dion

4-hydroxy-6-methyl-2-pyridone