(R)-1-benzyloxy-4-methyl-2-oxo-3-(1-phenylethylamino)-2,5-dihydropyrrole

Base Information

Chemical Name:(R)-1-benzyloxy-4-methyl-2-oxo-3-(1-phenylethylamino)-2,5-dihydropyrrole
CAS No.:130865-71-3
Molecular Formula:C20H22N2O2
Molecular Weight:322.407
Hs Code.:
DSSTox Substance ID:DTXSID601129358

Synonyms:SCHEMBL9188463;LWESSNUJYORHBV-MRXNPFEDSA-N;DTXSID601129358;(R)-1-benzyloxy-4-methyl-2-oxo-3-(1-phenylethylamino)-2,5-dihydropyrrole;130865-71-3;1,5-Dihydro-4-methyl-3-[[(1R)-1-phenylethyl]amino]-1-(phenylmethoxy)-2H-pyrrol-2-one

Suppliers and Price of (R)-1-benzyloxy-4-methyl-2-oxo-3-(1-phenylethylamino)-2,5-dihydropyrrole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-benzyloxy-4-methyl-2-oxo-3-(1-phenylethylamino)-2,5-dihydropyrrole

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:322.168127949
Heavy Atom Count:24
Complexity:462

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=O)N(C1)OCC2=CC=CC=C2)NC(C)C3=CC=CC=C3
Isomeric SMILES:CC1=C(C(=O)N(C1)OCC2=CC=CC=C2)N[C@H](C)C3=CC=CC=C3

Technology Process of (R)-1-benzyloxy-4-methyl-2-oxo-3-(1-phenylethylamino)-2,5-dihydropyrrole

There total 12 articles about (R)-1-benzyloxy-4-methyl-2-oxo-3-(1-phenylethylamino)-2,5-dihydropyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 130865-70-2
1-benzyloxy-4-methyl-pyrrolidine-2,2-dione

: 130865-71-3
(R) 1-benzyloxy-4-methyl-2-oxo-3-(1-phenylethylamino)-2,5-dihydropyrrole

Guidance literature:: In methanol; for 23h; Reflux;
DOI:10.1016/j.tetlet.2008.07.172

Reference yield: 78.0%

: 130865-71-3
(R) 1-benzyloxy-4-methyl-2-oxo-3-(1-phenylethylamino)-2,5-dihydropyrrole

Guidance literature:

Reference yield:

: 70423-44-8
(Z)-4,4-Dimethoxy-3-methyl-crotonsaeureaethylester

: 130865-71-3
(R) 1-benzyloxy-4-methyl-2-oxo-3-(1-phenylethylamino)-2,5-dihydropyrrole

Guidance literature:: Multi-step reaction with 9 steps

1: H₂ / Pd/C

2: Dowex 50W-X₈ (H⁺ form) / acetone

3: Et₃N

4: NaCNBH₃, HCl

5: NaOMe / methanol

6: N-phenylsulfonyl-3-phenyloxaziridine, KN(SiMe₃)2 / toluene / -90 °C

7: Me₂SO

8: i-Pr₂NEt

9: methanol / 55 °C

With hydrogenchloride; Dowex 50W-X₈ (H⁺ form); hydrogen; sodium methylate; potassium hexamethylsilazane; sodium cyanoborohydride; dimethyl sulfoxide; N-(benzenesulfonyl)-3-phenyloxaziridine; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; acetone; toluene;
DOI:10.1039/c39900001578