2-ChloroMethyl-5-trifluoroMethyl-benzooxazole

Base Information

• Chemical Name: 2-ChloroMethyl-5-trifluoroMethyl-benzooxazole
• CAS No.: 131337-75-2
• Molecular Formula: C9H5ClF3NO
• Molecular Weight: 235.593
• Hs Code.: 2934999090
• Mol file: 131337-75-2.mol

Synonyms:2-(chloromethyl)-5-(trifluoromethyl)benzoxazole;2-chloromethyl-5-trifluoromethyl-benzoxazole;2-(CHLOROMETHYL)-5-(TRIFLUOROMETHYL)-1,3-BENZOXAZOLE;

Chemical Property of 2-ChloroMethyl-5-trifluoroMethyl-benzooxazole

Chemical Property:

• PSA: 26.03000
• LogP: 3.58540

Purity/Quality:

97% ^*data from raw suppliers

2-(Chloromethyl)-5-(trifluoromethyl)-1,3-benzoxazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ChloroMethyl-5-trifluoroMethyl-benzooxazole

There total 3 articles about 2-ChloroMethyl-5-trifluoroMethyl-benzooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-chloro-1,1,1-triethoxyethane (51076-95-0) + 2-amino-4-(trifluoromethyl)phenol (454-81-9) → 2-(chloromethyl)-5-(trifluoromethyl)benzo[d]oxazole (131337-75-2)

Guidance literature:

With acetic acid; Heating;

Reference yield: 27.0%

2-amino-4-(trifluoromethyl)phenol (454-81-9) + chloroacetyl chloride (79-04-9) → 2-(chloromethyl)-5-(trifluoromethyl)benzo[d]oxazole (131337-75-2)

Guidance literature:

2-amino-4-(trifluoromethyl)phenol; chloroacetyl chloride; In 5,5-dimethyl-1,3-cyclohexadiene; at 0 ℃; for 2h;

With triethylamine; In 5,5-dimethyl-1,3-cyclohexadiene; for 15h; Reflux;

Reference yield:

2-nitro-4-trifluoromethylphenol (400-99-7) → 2-(chloromethyl)-5-(trifluoromethyl)benzo[d]oxazole (131337-75-2)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 760.05 Torr

2: acetic acid / Heating

With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol;

upstream raw materials:

2-chloro-1,1,1-triethoxyethane

2-amino-4-(trifluoromethyl)phenol

2-nitro-4-trifluoromethylphenol

chloroacetyl chloride

Downstream raw materials:

(p-methoxyphenyl)methyl 3,4-dihydro-4-oxo-3-<<5-(trifluoromethyl)-2-benzoxazolyl>methyl>-1-phthalazineacetate

N-{[4-ethyl-5-({[5-(trifluoromethyl)-1,3-benzoxazol-2-yl]methyl}sulfanyl)-4H-1,2,4-triazol-3-yl]methyl}aniline

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