N-Methyl-2-(methylthio)aniline

Base Information

• Chemical Name: N-Methyl-2-(methylthio)aniline
• CAS No.: 13372-62-8
• Molecular Formula: C8H11NS
• Molecular Weight: 153.248
• Hs Code.: 2930909090
• Mol file: 13372-62-8.mol

Synonyms:N-Methyl-2-methylmercapto-anilin;N-methyl-o-aminophenyl methyl sulphide;N-methyl-2-(methylsulfanyl)aniline;Benzenamine,N-methyl-2-(methylthio);o-methylmercapto-N-methylaniline;methyl N-methyl-o-aminophenyl sulphide;N-methyl-o-methylthioaniline;N-Methyl-2-(methylthio)anilin;

Chemical Property of N-Methyl-2-(methylthio)aniline

Chemical Property:

• PSA: 37.33000
• LogP: 2.52320

Purity/Quality:

99.90% ^*data from raw suppliers

N-methyl-2-(methylsulfanyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Methyl-2-(methylthio)aniline

There total 22 articles about N-Methyl-2-(methylthio)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,3-dimethylbenzothiazolium iodide (2785-06-0) → 1,3-Benzothiazole (95-16-9) + 2-Methylbenzothiazole (120-75-2) + 2,2,3-trimethylbenzo-1,3-thiazoline (2786-37-0) + 3-Methyl-2-methylene-2,3-dihydro-benzothiazole (23574-67-6) + N-methyl-o-aminophenyl methyl sulphide (13372-62-8) + 2,3-Dimethylbenzthiazoliummethosulfat (38925-99-4)

Guidance literature:

at 300 ℃; Product distribution; Mechanism; relative percentage of isolated volatile products of thermolysis;

DOI:10.1007/BF00506989

Reference yield: 85.0%

methanol (67-56-1) + 2-(Methylthio)aniline (2987-53-3) → N-methyl-o-aminophenyl methyl sulphide (13372-62-8)

Guidance literature:

With C₃₁H₃₀ClIrN₃O⁽¹⁺⁾*F₆P^(1-); potassium tert-butylate; at 130 ℃; for 24h;

DOI:10.1039/c9dt00218a

Reference yield: 60.0%

N-methyl-N-(2-(methylthio)phenyl)acetamide (91799-47-2) → N-methyl-o-aminophenyl methyl sulphide (13372-62-8)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 24h; Reflux;

DOI:10.1039/d0cc08096a

upstream raw materials:

2-(methylamino)benzenethiol

2-<(2,3-Dihydro-3-methylbenzothiazol-2-yliden)methyl>-2,3-dihydro-3-methylbenzothiazol

2,3-dimethylbenzothiazolium iodide

3-Methyl-2-{(E)-3-[3-methyl-3H-benzothiazol-(2E)-ylidene]-propenyl}-benzothiazol-3-ium; iodide

Downstream raw materials:

4'-Carboxy-3-methylmercapto-4-amino-azobenzol

3-chloro-N-methyl-(2-methylthio)phenyl-propionamide

3-Methylmercapto-N-methyl-4-amino-azobenzol

3-Methylmercapto-4-amino-azobenzol

Refernces

• 1、 Katselou, Maria G.,Matralis, Alexios N.,Kourounakis, Angeliki P.. "Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity". . p. 748 - 760. Retrieved 2017.
• 2、 Huang, Shuang,Hong, Xi,Cui, He-Zhen,Zhan, Bing,Li, Zhi-Ming,Hou, Xiu-Feng. "Bimetallic Bis-NHC-Ir(III) Complex Bearing 2-Arylbenzo[d]oxazolyl Ligand: Synthesis, Catalysis, and Bimetallic Effects". . p. 3514 - 3523. Retrieved 2020/10/09.