(3E)-3-(Benzylidene)-5-[4-chlorophenyl]furan-2(3H)-one

Base Information

• Chemical Name: (3E)-3-(Benzylidene)-5-[4-chlorophenyl]furan-2(3H)-one
• CAS No.: 134529-28-5
• Molecular Formula: C17H11ClO2
• Molecular Weight: 282.726
• Mol file: 134529-28-5.mol

Synonyms:5-(4-Chloro-phenyl)-3-[1-phenyl-meth-(E)-ylidene]-3H-furan-2-one;

Chemical Property of (3E)-3-(Benzylidene)-5-[4-chlorophenyl]furan-2(3H)-one

Chemical Property:

• Melting Point: 194 °C (chloroform)
• PSA: 26.30000
• LogP: 4.32130

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3E)-3-(Benzylidene)-5-[4-chlorophenyl]furan-2(3H)-one

There total 4 articles about (3E)-3-(Benzylidene)-5-[4-chlorophenyl]furan-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-Chloro-4-iodobenzene (637-87-6) + carbon monoxide (201230-82-2) + propargyl benzene (10147-11-2) → (E)-3-benzylidene-5-(4-chlorophenyl)furan-2(3H)-one (134529-28-5)

Guidance literature:

With trifuran-2-yl-phosphane; palladium diacetate; N-ethyl-N,N-diisopropylamine; at 25 ℃; for 20h; under 750.075 Torr; Inert atmosphere;

DOI:10.1002/chem.201202138

Reference yield: 85.0%

bromochlorobenzene (106-39-8) + carbon monoxide (201230-82-2) + propargyl benzene (10147-11-2) → (E)-3-benzylidene-5-(4-chlorophenyl)furan-2(3H)-one (134529-28-5)

Guidance literature:

With 4,5’-bis(diphenylphosphino)-9,9’-dimethylxanthene; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; triethylamine; In toluene; at 110 ℃; for 20h; under 7500.75 Torr; Autoclave;

DOI:10.1002/chem.201101083

Reference yield: 67.0%

carbon monoxide (201230-82-2) + propargyl benzene (10147-11-2) + 4-chlorophenyl trifluoromethanesulfonate (29540-84-9) → (E)-3-benzylidene-5-(4-chlorophenyl)furan-2(3H)-one (134529-28-5)

Guidance literature:

With 4,5’-bis(diphenylphosphino)-9,9’-dimethylxanthene; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; triethylamine; In toluene; at 110 ℃; for 20h; under 7500.75 Torr; Autoclave;

DOI:10.1002/chem.201101083

upstream raw materials:

4-(4-chlorophenyl)-4-oxobutanoic acid

benzaldehyde

1-Chloro-4-iodobenzene

carbon monoxide

Downstream raw materials:

C₂₄H₂₀ClNO₂

5-benzyl-3-(4-chlorophenyl)-1,6-dihydro-6-pyridazinone