1-(6-Methoxy-1-naphthyl)ethan-1-one

Base Information

• Chemical Name: 1-(6-Methoxy-1-naphthyl)ethan-1-one
• CAS No.: 58149-89-6
• Molecular Formula: C13H12 O2
• Molecular Weight: 200.237
• European Community (EC) Number: 261-142-9
• UNII: 48MK5PP3PT
• DSSTox Substance ID: DTXSID40206887
• Nikkaji Number: J296.885A
• Wikidata: Q83080757
• Mol file: 58149-89-6.mol

Synonyms:58149-89-6;1-(6-methoxynaphthalen-1-yl)ethanone;1-(6-Methoxy-1-naphthyl)ethan-1-one;EINECS 261-142-9;48MK5PP3PT;Ethanone, 1-(6-methoxy-1-naphthalenyl)-;1-(6-METHOXYNAPHTHALEN-1-YL)ETHAN-1-ONE;1-(6-Methoxy-1-naphthyl)ethanone;UNII-48MK5PP3PT;6-Methoxy-1-acetonaphthone;1-Acetyl-6-methoxynaphthalene;SCHEMBL9747620;DTXSID40206887;1-(6-Methoxy-1-naphthyl)ethanone #;1-(6-METHOXY-1-NAPHTHALENYL)ETHANONE

Chemical Property of 1-(6-Methoxy-1-naphthyl)ethan-1-one

Chemical Property:

• Vapor Pressure: 7.04E-05mmHg at 25°C
• Boiling Point: 343.4°Cat760mmHg
• Flash Point: 158.9°C
• PSA: 26.30000
• Density: 1.118g/cm³
• LogP: 3.05100
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 200.083729621
• Heavy Atom Count: 15
• Complexity: 237

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC=CC2=C1C=CC(=C2)OC

Technology Process of 1-(6-Methoxy-1-naphthyl)ethan-1-one

There total 16 articles about 1-(6-Methoxy-1-naphthyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

6-methoxy-1-naphthoic acid (36112-61-5) + methyllithium (917-54-4) → 1-(6-methoxynaphthalen-1-yl)ethanone (58149-89-6)

Guidance literature:

In diethyl ether; at 0 ℃; for 24h;

DOI:10.1021/jo00324a039

Reference yield: 56.0%

2-Methoxynaphthalene (93-04-9) + acetic anhydride (108-24-7) → 6-methoxy-2-acetylnaphthalene (3900-45-6) + 1-(6-methoxynaphthalen-1-yl)ethanone (58149-89-6)

Guidance literature:

With phosphotungstic acid; In tetrachloromethane; at 140 ℃; for 3h; Solvent; regioselective reaction; Reflux;

DOI:10.1016/j.apcata.2014.08.026

Reference yield: 2.0%

4,6-dimethoxy-1-naphthylmethyl ketone (42200-95-3) → 1-(6-methoxynaphthalen-1-yl)ethanone (58149-89-6) + 6-methoxy-1-naphthol (22604-07-5) + 6-methoxy-1-naphthoic acid (36112-61-5)

Guidance literature:

With ammonium chloride; sodium; In tetrahydrofuran; ethanol; ammonia; for 4h;

DOI:10.1016/S0040-4020(01)98894-5

upstream raw materials:

6-methoxy-1-naphthoyl chloride

dimethylcadmium

6-methoxy-1-naphthoic acid

diethyl (ethoxymagnesio)malonate

Downstream raw materials:

2-(6-methoxy-1-naphthyl)-1-phenyl-2-propanol