Butanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-4-hydroxy-, Methyl ester, (3S)-

Base Information

Chemical Name:Butanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-4-hydroxy-, Methyl ester, (3S)-
CAS No.:136703-59-8
Molecular Formula:C10H19NO5
Molecular Weight:233.265
Hs Code.:
Mol file:136703-59-8.mol

Synonyms:methyl (3S)-3-(N-BOC-amino)-4-hydroxybutanoate;methyl 3-(S)-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoate;methyl 3-(S)-(t-butoxycarbonylamino)-4-hydroxybutanoate;Butanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-4-hydroxy-, Methyl ester, (3S)-;(S)-methyl [3-(tert-butoxycarbonyl)amino]-4-hydroxybutanoate;(S)-methyl 3-(t-butoxycarbonylamino)-4-hydroxybutanoate;methyl 3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoate;

Suppliers and Price of Butanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-4-hydroxy-, Methyl ester, (3S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(3S)?-3-[[(1,1-Dimethylethoxy)?carbonyl]?amino]?-4-hydroxy-butanoicAcidMethylEster
2.5g
$ 1230.00

AK Scientific
Methyl(S)-3-(Boc-amino)-4-hydroxybutanoate
1g
$ 505.00

Total 6 raw suppliers

Chemical Property of Butanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-4-hydroxy-, Methyl ester, (3S)-

Chemical Property:

Boiling Point:364.6±37.0 °C(Predicted)
PKA:11.25±0.46(Predicted)
PSA：84.86000
Density:1.125±0.06 g/cm3(Predicted)
LogP:0.82600

Purity/Quality:

97% ^*data from raw suppliers

(3S)?-3-[[(1,1-Dimethylethoxy)?carbonyl]?amino]?-4-hydroxy-butanoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (3S)?-3-[[(1,1-Dimethylethoxy)?carbonyl]?amino]?-4-hydroxy-butanoic Acid Methyl Ester is used to prepare CCR3 antagonists with picomolar inhibition potency against eosinophil chemotaxis. It is also used to synthesize aryl substituted, β- and γ-amino acids in DMF using functionalized zinc reagents.

Technology Process of Butanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-4-hydroxy-, Methyl ester, (3S)-

There total 16 articles about Butanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-4-hydroxy-, Methyl ester, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 59768-74-0,124184-67-4
(S)-2-t-butoxycarbonylaminosuccinic acid 4-methyl ester

: 136703-59-8
(3S)-3-[(tert-butoxycarbonyl)amino]-4-hydroxybutanoic acid methyl ester

Guidance literature:: (S)-2-t-butoxycarbonylaminosuccinic acid 4-methyl ester; With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In ethyl acetate; at 0 - 20 ℃; for 16h; Inert atmosphere;

With sodium tetrahydroborate; In tetrahydrofuran; water; for 0.1h; Inert atmosphere;
DOI:10.1021/acs.joc.7b02799