Ethyl 2,3-dihydrobenzofuran-2-carboxylate

Base Information

• Chemical Name: Ethyl 2,3-dihydrobenzofuran-2-carboxylate
• CAS No.: 43119-53-5
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• DSSTox Substance ID: DTXSID50962907
• Nikkaji Number: J2.653.267A
• Mol file: 43119-53-5.mol

Synonyms:ethyl 2,3-dihydrobenzofuran-2-carboxylate

Chemical Property of Ethyl 2,3-dihydrobenzofuran-2-carboxylate

Chemical Property:

• Vapor Pressure: 0.0048mmHg at 25°C
• Boiling Point: 276.5°Cat760mmHg
• Flash Point: 110.8°C
• Density: 1.174g/cm³
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 192.078644241
• Heavy Atom Count: 14
• Complexity: 215

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1CC2=CC=CC=C2O1

Technology Process of Ethyl 2,3-dihydrobenzofuran-2-carboxylate

There total 22 articles about Ethyl 2,3-dihydrobenzofuran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

ethyl 2-(2-(bromomethyl)phenoxy)acetate (74225-91-5) → ethyl 2,3-dihydro-1-benzofuran-2-carboxylate (43119-53-5) + ethyl (2-methylphenoxy)acetate (93917-68-1)

Guidance literature:

With tetramethylammonium tetrafluoroborate; In N,N-dimethyl-formamide; Concentration; Electrolysis; Inert atmosphere;

DOI:10.1149/1945-7111/ab72ef

Reference yield: 43.0%

ethyl 2-(2-(bromomethyl)phenoxy)acetate (74225-91-5) → ethyl coumarilate (3199-61-9) + ethyl 2,3-dihydro-1-benzofuran-2-carboxylate (43119-53-5)

Guidance literature:

With tetramethylammonium tetrafluoroborate; In N,N-dimethyl-formamide; Concentration; Electrolysis;

DOI:10.1149/1945-7111/ab72ef

Reference yield: 42.0%

ethyl (dimethylsulfuranylidene)acetate (7380-81-6) + 2-((tert-butyldimethylsilyl)oxy)benzyl bromide (105262-86-0) → ethyl 2,3-dihydro-1-benzofuran-2-carboxylate (43119-53-5)

Guidance literature:

With tetrabutyl ammonium fluoride; caesium carbonate; In tetrahydrofuran; dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c4ra17003b

upstream raw materials:

(+/-)-2-ethenyl-2,3-dihydrobenzofuran

ethanol

o-(ethoxycarbonylmethoxy)benzyl chloride

6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid ethyl ester

Downstream raw materials:

2,3-dihydro-1-benzofuran-2-carboxylic acid

ethyl coumarilate