Ethyl 2-[2-(chloromethyl)phenoxy]acetate

Base Information

Chemical Name:Ethyl 2-[2-(chloromethyl)phenoxy]acetate
CAS No.:111080-49-0
Molecular Formula:C₁₁H₁₃ClO₃
Molecular Weight:228.675
Hs Code.:
DSSTox Substance ID:DTXSID901276619

Synonyms:Ethyl 2-[2-(chloromethyl)phenoxy]acetate;111080-49-0;DTXSID901276619;AKOS005216093;ethyl [2-(chloromethyl)phenoxy]acetate

Suppliers and Price of Ethyl 2-[2-(chloromethyl)phenoxy]acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 2-[2-(chloromethyl)phenoxy]acetate

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:228.0553220
Heavy Atom Count:15
Complexity:196

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)COC1=CC=CC=C1CCl

Technology Process of Ethyl 2-[2-(chloromethyl)phenoxy]acetate

There total 4 articles about Ethyl 2-[2-(chloromethyl)phenoxy]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 111080-48-9
ethyl 2-[2-(hydroxymethyl)phenoxy]acetate

: 111080-49-0
o-(ethoxycarbonylmethoxy)benzyl chloride

Guidance literature:: With thionyl chloride; In dichloromethane; at 0 ℃; for 0.25h;
DOI:10.1039/b205436a

Reference yield:

: 41873-61-4
ethyl (2-formylphenoxy)acetate

: 111080-49-0
o-(ethoxycarbonylmethoxy)benzyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / NaBH₄ / methanol / 0.25 h / -5 - 0 °C

2: 92 percent / SOCl₂ / CH₂Cl₂ / 0.25 h / 0 °C

With sodium tetrahydroborate; thionyl chloride; In methanol; dichloromethane;
DOI:10.1039/b205436a

Reference yield:

: 90-02-8
salicylaldehyde

: 111080-49-0
o-(ethoxycarbonylmethoxy)benzyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / K₂CO₃, KI / dimethylformamide / 20 h / Ambient temperature

2: 100 percent / 1.) C₂H₅ONa; 2.) NaBH₄ / ethanol / 1.) 0-5 deg C; 2.) below 8 deg C, 3.75 h

3: 78 percent / SOCl₂, pyridine / CH₂Cl₂ / 1.5 h / Heating

With pyridine; sodium tetrahydroborate; thionyl chloride; sodium ethanolate; potassium carbonate; potassium iodide; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570240236