Cytidine, 2'-deoxy-, 3-oxide

Base Information

• Chemical Name: Cytidine, 2'-deoxy-, 3-oxide
• CAS No.: 137017-42-6
• Molecular Formula: C9H13N3O5
• Mol file: 137017-42-6.mol

Synonyms:

Chemical Property of Cytidine, 2'-deoxy-, 3-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cytidine, 2'-deoxy-, 3-oxide

There total 1 articles about Cytidine, 2'-deoxy-, 3-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2'-Deoxycytidine (951-77-9) → 4-amino-1-(4-hydroxy-5-hydroxymethyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one 3-oxide (137017-42-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In methanol; at 20 ℃;

DOI:10.1021/jo0486241

Reference yield: 90.0%

benzyl bromide (100-39-0) + 4-amino-1-(4-hydroxy-5-hydroxymethyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one 3-oxide (137017-42-6) → 1-(4-hydroxy-5-hydroxymethyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 4-(O-benzyloxime)

Guidance literature:

With methanol; lithium hydride; at 37 ℃; for 24h;

DOI:10.1021/jo0486241

upstream raw materials:

2'-Deoxycytidine

Refernces

• 1、 Itahara, Toshio. "Oxidation of Cytosine and 5-Methylcytosine Nucleosides and 5-Methyl-2'-deoxycytidine 5'-Monophosphate with Peroxosulfate Ions". . p. 1591 - 1594. Retrieved 2007/10/02.