2-Thiophenecarboxaldehyde, 5-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[5-methyl-2-(4-methylphenyl) -4-oxazolyl]propyl]-

Base Information

Chemical Name:2-Thiophenecarboxaldehyde, 5-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[5-methyl-2-(4-methylphenyl) -4-oxazolyl]propyl]-
CAS No.:137090-30-3
Molecular Formula:C₂₅H₃₃NO₃SSi
Molecular Weight:455.693
Hs Code.:
Mol file:137090-30-3.mol

Synonyms:

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Chemical Property of 2-Thiophenecarboxaldehyde, 5-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[5-methyl-2-(4-methylphenyl) -4-oxazolyl]propyl]-

Chemical Property:

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Technology Process of 2-Thiophenecarboxaldehyde, 5-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[5-methyl-2-(4-methylphenyl) -4-oxazolyl]propyl]-

There total 6 articles about 2-Thiophenecarboxaldehyde, 5-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-[5-methyl-2-(4-methylphenyl) -4-oxazolyl]propyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5370-25-2
2-Acetyl-5-bromothiophene

: 137090-30-3
5-[1-(Dimethyl-t-butylsilyloxy)-3-(2-(4-methylphenyl)-5-methyl-4-oxazolyl)propyl]thiophene-2-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / sodium hydride / tetrahydrofuran / 1 h

2: 1.) sodium hydride / 1.) THF, RT, 0.5 h, 2.) THF, reflux, 48 h

3: sodium borohydride / ethanol / 1 h

4: imidazole / dimethylformamide / 36 h / Ambient temperature

5: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, DMF, -78 deg C, 1 h

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; sodium hydride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00088a022

Reference yield:

: 137090-42-7
methyl 3-(5-bromothiophen-2-yl)-3-oxopropionate

: 137090-30-3
5-[1-(Dimethyl-t-butylsilyloxy)-3-(2-(4-methylphenyl)-5-methyl-4-oxazolyl)propyl]thiophene-2-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sodium hydride / 1.) THF, RT, 0.5 h, 2.) THF, reflux, 48 h

2: sodium borohydride / ethanol / 1 h

3: imidazole / dimethylformamide / 36 h / Ambient temperature

4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, DMF, -78 deg C, 1 h

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; sodium hydride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00088a022

Reference yield:

: 141200-98-8
5-bromo-2-<1-hydroxy-3-<2-(4-methylphenyl)-5-methyl-4-oxazolyl>propyl>thiophene

: 137090-30-3
5-[1-(Dimethyl-t-butylsilyloxy)-3-(2-(4-methylphenyl)-5-methyl-4-oxazolyl)propyl]thiophene-2-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: imidazole / dimethylformamide / 36 h / Ambient temperature

2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, DMF, -78 deg C, 1 h

With 1H-imidazole; n-butyllithium; In N,N-dimethyl-formamide;
DOI:10.1021/jm00088a022