5-[1-{5-[1-(tert-Butyl-dimethyl-silanyloxy)-3-(5-methyl-2-p-tolyl-oxazol-4-yl)-propyl]-thiophen-2-yl}-meth-(E)-ylidene]-thiazolidine-2,4-dione

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Chemical Name:5-[1-{5-[1-(tert-Butyl-dimethyl-silanyloxy)-3-(5-methyl-2-p-tolyl-oxazol-4-yl)-propyl]-thiophen-2-yl}-meth-(E)-ylidene]-thiazolidine-2,4-dione
CAS No.:137090-31-4
Molecular Formula:C₂₈H₃₄N₂O₄S₂Si
Molecular Weight:554.806
Hs Code.:

Synonyms:5-[1-{5-[1-(tert-Butyl-dimethyl-silanyloxy)-3-(5-methyl-2-p-tolyl-oxazol-4-yl)-propyl]-thiophen-2-yl}-meth-(E)-ylidene]-thiazolidine-2,4-dione

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Chemical Property of 5-[1-{5-[1-(tert-Butyl-dimethyl-silanyloxy)-3-(5-methyl-2-p-tolyl-oxazol-4-yl)-propyl]-thiophen-2-yl}-meth-(E)-ylidene]-thiazolidine-2,4-dione

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Technology Process of 5-[1-{5-[1-(tert-Butyl-dimethyl-silanyloxy)-3-(5-methyl-2-p-tolyl-oxazol-4-yl)-propyl]-thiophen-2-yl}-meth-(E)-ylidene]-thiazolidine-2,4-dione

There total 6 articles about 5-[1-{5-[1-(tert-Butyl-dimethyl-silanyloxy)-3-(5-methyl-2-p-tolyl-oxazol-4-yl)-propyl]-thiophen-2-yl}-meth-(E)-ylidene]-thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5370-25-2
2-Acetyl-5-bromothiophene

: 137090-31-4
5-[1-{5-[1-(tert-Butyl-dimethyl-silanyloxy)-3-(5-methyl-2-p-tolyl-oxazol-4-yl)-propyl]-thiophen-2-yl}-meth-(E)-ylidene]-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / sodium hydride / tetrahydrofuran / 1 h

2: 1.) sodium hydride / 1.) THF, RT, 0.5 h, 2.) THF, reflux, 48 h

3: sodium borohydride / ethanol / 1 h

4: imidazole / dimethylformamide / 36 h / Ambient temperature

5: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, DMF, -78 deg C, 1 h

6: sodium acetate / 2 h / 140 °C

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; sodium acetate; sodium hydride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00088a022

Reference yield:

: 137090-42-7
methyl 3-(5-bromothiophen-2-yl)-3-oxopropionate

: 137090-31-4
5-[1-{5-[1-(tert-Butyl-dimethyl-silanyloxy)-3-(5-methyl-2-p-tolyl-oxazol-4-yl)-propyl]-thiophen-2-yl}-meth-(E)-ylidene]-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) sodium hydride / 1.) THF, RT, 0.5 h, 2.) THF, reflux, 48 h

2: sodium borohydride / ethanol / 1 h

3: imidazole / dimethylformamide / 36 h / Ambient temperature

4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, DMF, -78 deg C, 1 h

5: sodium acetate / 2 h / 140 °C

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; sodium acetate; sodium hydride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00088a022

Reference yield:

: 137090-45-0
5-bromo-2-<3-(2-(4-methylphenyl)-5-methyl-4-oxazolyl)propionyl>thiophene

: 137090-31-4
5-[1-{5-[1-(tert-Butyl-dimethyl-silanyloxy)-3-(5-methyl-2-p-tolyl-oxazol-4-yl)-propyl]-thiophen-2-yl}-meth-(E)-ylidene]-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: sodium borohydride / ethanol / 1 h

2: imidazole / dimethylformamide / 36 h / Ambient temperature

3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, DMF, -78 deg C, 1 h

4: sodium acetate / 2 h / 140 °C

With 1H-imidazole; sodium tetrahydroborate; n-butyllithium; sodium acetate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00088a022