alpha-(4-Chlorophenyl)-alpha-[4-(4-pyridyl)phenyl]-1H-imidazole-1-ethanol

Base Information

Chemical Name:alpha-(4-Chlorophenyl)-alpha-[4-(4-pyridyl)phenyl]-1H-imidazole-1-ethanol
CAS No.:137103-64-1
Molecular Formula:C₂₂H₁₈ClN₃O
Molecular Weight:375.857
Hs Code.:
DSSTox Substance ID:DTXSID40875355
Nikkaji Number:J491.826F
ChEMBL ID:CHEMBL110464

Synonyms:137103-64-1;CHEMBL110464;SCHEMBL9202987;DTXSID40875355;1H-IMIDAZOLE-1-ETHANOL, alpha-(4-CHLOROPHENYL)-a;alpha-(4-Chlorophenyl)-alpha-[4-(4-pyridyl)phenyl]-1H-imidazole-1-ethanol

Suppliers and Price of alpha-(4-Chlorophenyl)-alpha-[4-(4-pyridyl)phenyl]-1H-imidazole-1-ethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of alpha-(4-Chlorophenyl)-alpha-[4-(4-pyridyl)phenyl]-1H-imidazole-1-ethanol

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:375.1138399
Heavy Atom Count:27
Complexity:457

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=CC=NC=C2)C(CN3C=CN=C3)(C4=CC=C(C=C4)Cl)O

Technology Process of alpha-(4-Chlorophenyl)-alpha-[4-(4-pyridyl)phenyl]-1H-imidazole-1-ethanol

There total 5 articles about alpha-(4-Chlorophenyl)-alpha-[4-(4-pyridyl)phenyl]-1H-imidazole-1-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1120-87-2
4-bromopyridin

: 137103-64-1
1-(4-chlorophenyl)-1-[4-(pyridin-4-yl)phenyl]-2-(1-imidazolyl)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi, 2.) ZnCl₂, 3.) Ni(PPh₃)2Cl₂, DIBAL-H, 4.) HCl

2: 97 percent / Br₂, HBr, AcOH / 1.) 20 deg C, 30 min, 2.) a.) 70 deg C, 5 min, b.) 20 deg C, 5 h

3: 66 percent / tetrahydrofuran / 24 h / 20 °C

4: 1.) CeCl₃ / 1.) THF, -78 deg C, 1 h, 2.) THF, 20 deg C, 16 h

With hydrogenchloride; bis(triphenylphosphine)nickel(II) chloride; n-butyllithium; cerium(III) chloride; hydrogen bromide; bromine; diisobutylaluminium hydride; acetic acid; zinc(II) chloride; In tetrahydrofuran;
DOI:10.1021/jm00095a009

Reference yield:

: 53578-00-0
2-(4-Bromophenyl)-2,2-dimethoxyethane

: 137103-64-1
1-(4-chlorophenyl)-1-[4-(pyridin-4-yl)phenyl]-2-(1-imidazolyl)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi, 2.) ZnCl₂, 3.) Ni(PPh₃)2Cl₂, DIBAL-H, 4.) HCl

2: 97 percent / Br₂, HBr, AcOH / 1.) 20 deg C, 30 min, 2.) a.) 70 deg C, 5 min, b.) 20 deg C, 5 h

3: 66 percent / tetrahydrofuran / 24 h / 20 °C

4: 1.) CeCl₃ / 1.) THF, -78 deg C, 1 h, 2.) THF, 20 deg C, 16 h

With hydrogenchloride; bis(triphenylphosphine)nickel(II) chloride; n-butyllithium; cerium(III) chloride; hydrogen bromide; bromine; diisobutylaluminium hydride; acetic acid; zinc(II) chloride; In tetrahydrofuran;
DOI:10.1021/jm00095a009

Reference yield:

: 99-90-1
para-bromoacetophenone

: 137103-64-1
1-(4-chlorophenyl)-1-[4-(pyridin-4-yl)phenyl]-2-(1-imidazolyl)ethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / Dowex 50X₂ (acid form) / methanol / 1 h / 65 °C

2: 1.) n-BuLi, 2.) ZnCl₂, 3.) Ni(PPh₃)2Cl₂, DIBAL-H, 4.) HCl

3: 97 percent / Br₂, HBr, AcOH / 1.) 20 deg C, 30 min, 2.) a.) 70 deg C, 5 min, b.) 20 deg C, 5 h

4: 66 percent / tetrahydrofuran / 24 h / 20 °C

5: 1.) CeCl₃ / 1.) THF, -78 deg C, 1 h, 2.) THF, 20 deg C, 16 h

With hydrogenchloride; bis(triphenylphosphine)nickel(II) chloride; n-butyllithium; cerium(III) chloride; Dowex 50X₂ (acid form); hydrogen bromide; bromine; diisobutylaluminium hydride; acetic acid; zinc(II) chloride; In tetrahydrofuran; methanol;
DOI:10.1021/jm00095a009