(2S)-3-[4-(aminomethyl)phenyl]-2-[(tert-butoxycarbonyl)amino]propanoic acid

Base Information

• Chemical Name: (2S)-3-[4-(aminomethyl)phenyl]-2-[(tert-butoxycarbonyl)amino]propanoic acid
• CAS No.: 137452-49-4
• Molecular Formula: C15H22N2O4
• Molecular Weight: 294.351
• Mol file: 137452-49-4.mol

Synonyms:N-Boc-4-aminomethyl-L-phenylalanine;4-AMINOMETHYL-L-BOC-PHENYLALANINE;

Chemical Property of (2S)-3-[4-(aminomethyl)phenyl]-2-[(tert-butoxycarbonyl)amino]propanoic acid

Chemical Property:

• PSA: 101.65000
• LogP: 2.75690

Purity/Quality:

99% ^*data from raw suppliers

(2S)-3-[4-(Aminomethyl)phenyl]-2-[(tert-butoxy)carbonylamino]propanoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Boc-4-aminomethyl-L-phenylalanine is an important organic intermediate (building block) to synthetize substituted phenylalanine products.

Technology Process of (2S)-3-[4-(aminomethyl)phenyl]-2-[(tert-butoxycarbonyl)amino]propanoic acid

There total 5 articles about (2S)-3-[4-(aminomethyl)phenyl]-2-[(tert-butoxycarbonyl)amino]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-Boc-4-oximino-L-phenylalanine (137452-48-3) → L-Nα-Boc-4-(aminomethyl)phenylalanine (137452-49-4,215597-48-1)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; for 18h; under 760 Torr; Ambient temperature;

DOI:10.1080/00397919108019817

Reference yield: 41.0%

L-N-Boc-4-<(trichloroacetamide)methyl>phenylalanine (170157-59-2) → L-Nα-Boc-4-(aminomethyl)phenylalanine (137452-49-4,215597-48-1)

Guidance literature:

With sodium hydroxide; In ethanol; for 0.5h; Ambient temperature;

DOI:10.1021/jm00014a017

Reference yield:

(S)-2-Amino-3-{4-[(2,2,2-trichloro-acetylamino)-methyl]-phenyl}-propionic acid (170157-60-5) → L-Nα-Boc-4-(aminomethyl)phenylalanine (137452-49-4,215597-48-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 2-methyl-propan-2-ol / Ambient temperature

2: 41 percent / aq. NaOH / ethanol / 0.5 h / Ambient temperature

With sodium hydroxide; In ethanol; tert-butyl alcohol;

DOI:10.1021/jm00014a017

upstream raw materials:

N-Boc-4-oximino-L-phenylalanine

L-N-Boc-4-<(trichloroacetamide)methyl>phenylalanine

(S)-2-Amino-3-{4-[(2,2,2-trichloro-acetylamino)-methyl]-phenyl}-propionic acid

N-Boc-4-formyl-L-phenylalanine

Downstream raw materials:

(S)-2-tert-Butoxycarbonylamino-3-[4-(isopropylamino-methyl)-phenyl]-propionic acid

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