5'-N-methylcarboxamidoadenosine

Base Information

Chemical Name:5'-N-methylcarboxamidoadenosine
CAS No.:35788-27-3
Molecular Formula:C₁₁H₁₄N₆O₄
Molecular Weight:294.27
Hs Code.:
DSSTox Substance ID:DTXSID101168111
Nikkaji Number:J452.999E
Wikidata:Q76009734
Pharos Ligand ID:G9AYAXK6PBK9
ChEMBL ID:CHEMBL519809
Mol file:35788-27-3.mol

Synonyms:5'-N-methylcarboxamideadenosine;MECA

Suppliers and Price of 5'-N-methylcarboxamidoadenosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
5'-N-METHYLCARBOXAMIDOADENOSINE 95.00%
5MG
$ 496.11

Total 11 raw suppliers

Chemical Property of 5'-N-methylcarboxamidoadenosine

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：148.41000
Density:1.98g/cm³
LogP:-1.25420
Solubility.:0.1 M HCl: soluble
XLogP3:-1.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:2
Exact Mass:294.10765295
Heavy Atom Count:21
Complexity:412

Purity/Quality:

97% ^*data from raw suppliers

5'-N-METHYLCARBOXAMIDOADENOSINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T+
Statements: 28
Safety Statements: 28-36/37-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC(=O)C1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O
Isomeric SMILES:CNC(=O)[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)O

Technology Process of 5'-N-methylcarboxamidoadenosine

There total 8 articles about 5'-N-methylcarboxamidoadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 89177-37-7
methyl 1-[adenin-9-yl]-2,3-di-O-acetyl-β-D-ribofuronate

: 74-89-5
methylamine

: 35788-27-3
5'-N-methylcarboxamidoadenosine

Guidance literature:: In tetrahydrofuran; at 110 ℃; for 0.333333h; microwave irradiation;
DOI:10.1016/j.tet.2007.11.100

Reference yield: 43.0%

: 39491-51-5
5'-N-methyl-2',3'-O-isopropylidenecarboxamidoadenosine

: 35788-27-3
5'-N-methylcarboxamidoadenosine

Guidance literature:: With trifluoroacetic acid; for 0.5h; Ambient temperature;
DOI:10.1021/jm9804984

Reference yield:

: 19234-66-3
2',3'-isopropylideneadenosine-5'-carboxylic acid

: 35788-27-3
5'-N-methylcarboxamidoadenosine

Guidance literature:: Multi-step reaction with 3 steps

1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 3 h / 20 °C

2: dimethylformamide / 1 h / 20 °C

3: 80percent aq. TFA / 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm000150k