Technology Process of 7H-1,4-Dioxino[2,3-e]indole-2-methanol, 2,3-dihydro-,
4-methylbenzenesulfonate (ester)
There total 10 articles about 7H-1,4-Dioxino[2,3-e]indole-2-methanol, 2,3-dihydro-,
4-methylbenzenesulfonate (ester) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap;
In
dichloromethane;
for 23h;
Ambient temperature;
DOI:10.1021/jm00094a021
- Guidance literature:
-
With
hydrogen;
In
ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 96 percent / 1.0 N aq. NaOH / ethanol / 0.5 h / Heating
2: 1.) cyclohexene, 2.) triethylamine / 1.) 10percent Pd/C / 1.) ethyl acetate, reflux, 21 h, 2.) ethanol, reflux, 1 h
3: 84 percent / 4-(dimethylamino)pyridine / CH2Cl2 / Ambient temperature
4: 72 percent / NaOCH3 / methanol / -5 °C
5: 75 percent / xylene / 1.5 h / Heating
6: 99 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / Ambient temperature
7: 96 percent / LiOH*H2O / methanol; H2O / 1 h / 60 °C
8: 62 percent / 0.5 h / 257 °C
9: 87 percent / 4-(dimethylamino)pyridine / CH2Cl2 / 23 h / Ambient temperature
With
dmap; lithium hydroxide; sodium hydroxide; tetrabutyl ammonium fluoride; sodium methylate; triethylamine; cyclohexene;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; xylene;
DOI:10.1021/jm00094a021
