86734-60-3

Basic information

• Product Name: Benzaldehyde, 3-hydroxy-2-(phenylmethoxy)-
• Synonyms: 2-benzyloxy-3-hydroxy-benzaldehyde;Benzaldehyde,3-hydroxy-2-(phenylmethoxy);2-Benzyloxy-3-hydroxy-benzaldehyd
• CAS NO: 86734-60-3
• Molecular Formula: C14H12O3
• Molecular Weight: 228.247
• Mol File: 86734-60-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 90-91 °C(Solv: benzene (71-43-2))
• Boiling Point: 170-180 °C(Press: 0.1 Torr)
• Density: 1.238±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzaldehyde, 3-hydroxy-2-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 3-hydroxy-2-(phenylmethoxy)-(86734-60-3)
• EPA Substance Registry System: Benzaldehyde, 3-hydroxy-2-(phenylmethoxy)-(86734-60-3)

Safety Data

• Hazardous Substances Data: 86734-60-3(Hazardous Substances Data)

Upstream product

• 24677-78-9 2,3-dihydroxybenzaldehyde 
• 100-39-0 benzyl bromide 
• 1221065-15-1 2-(benzyloxy)-3-(methoxymethoxy)benzaldehyde 
• 100-44-7 benzyl chloride 

Downstream Products

• 137578-44-0 3-(oxiranylmethoxy)-2-(phenylmethoxy)benzaldehyde 
• 1221065-16-2 2-(benzyloxy)-3-formylphenyl trifluoromethanesulfonate 
• 114158-62-2 3-methanesulfonyloxy-2-methoxy-benzaldehyde 
• 108015-69-6 2-hydroxy-3-methanesulfonyloxy-benzaldehyde 
• 137578-37-1 2-[(3-Phenyl-propylamino)-methyl]-2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole-8-carboxylic acid (3-phenyl-propyl)-amide 
• 137578-35-9 2-[(3-Phenyl-propylamino)-methyl]-2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole-8-carboxylic acid methyl ester 
• 137578-28-0 2-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylmethyl)-2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole-8-carboxylic acid benzyl ester 
• 137578-27-9 2-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylmethyl)-2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole-8-carboxylic acid butyl ester 
• 137578-23-5 2-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylmethyl)-2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole-8-carboxylic acid methyl ester 
• 137578-33-7 2-(4-Carbamoyl-4-phenylamino-piperidin-1-ylmethyl)-2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole-8-carboxylic acid methyl ester 
• 137578-25-7 2-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylmethyl)-2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole-8-carboxylic acid amide 
• 137578-24-6 2-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylmethyl)-2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole-8-carboxylic acid 
• 137578-39-3 8-(8-Hydroxymethyl-2,3-dihydro-7H-[1,4]dioxino[2,3-e]indol-2-ylmethyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one 
• 137578-26-8 2-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylmethyl)-2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole-8-carbonitrile 

Relevant articles and documents

CARBOXYLIC ACID DERIVATIVE AS AT2R RECEPTOR ANTAGONIST

The present invention relates to a compound shown in formula (II) or a pharmaceutically acceptable salt thereof and an application of the same in preparing a drug for treating a disease related to angiotensin II receptor type 2 (AT2R).(II)

Expeditious synthesis of benzopyrans via lewis acid-catalyzed C-H functionalization: Remarkable enhancement of reactivity by an ortho substituent

An expeditious construction of a benzopyran skeleton via Lewis acid-catalyzed C-H functionalization was achieved. In this process, a [1,5] hydride shift and 6-endo cyclization successively occurred to give benzopyrans. The presence of substituents ortho to the alkoxy group significantly enhanced the reactivity, affording the desired compounds in excellent chemical yields with short reaction times.

Modulation of selective serotonin reuptake inhibitor and 5-HT1A antagonist activity in 8-aza-bicyclo[3.2.1]octane derivatives of 2,3-dihydro-1,4-benzodioxane

2,3-Dihydro-1,4-benzodioxanes with aryl 8-aza-bicyclo[3.2.1]oct-3-ene attachments 2 produce compounds with potent 5-HT-T affinity, and weak 5-HT 1A affinity and α1 affinity. This compares with 2,3-dihydro-1,4-benzodioxanes containing 8-aza-bicyclo[3.2.1] octan-3-ol attachments 4 which possess potent 5-HT1A affinity, moderate to good selectivity over α1 and little 5-HT-T affinity. A 3-benzothiophene analogue of 4 (30) was synthesized which possesses potent 5-HT1A affinity and especially good selectivity over both α1 and 5-HT-T.