86734-60-3

Upstream product

• 24677-78-9 2,3-dihydroxybenzaldehyde 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 1221065-15-1 2-(benzyloxy)-3-(methoxymethoxy)benzaldehyde 

Downstream Products

• 109442-65-1 2-benzyloxy-3-methanesulfonyloxy-benzaldehyde 
• 137578-44-0 3-(oxiranylmethoxy)-2-(phenylmethoxy)benzaldehyde 
• 131866-67-6 2-(benzyloxy)-3-ethoxybenzaldehyde 
• 497147-92-9 2-benzyloxy-3-ethynyl-phenol 
• 2011-06-5 2-benzyloxy-3-methoxybenzaldehyde 
• 137578-53-1 2,3-Dihydro-7H-[1,4]dioxino[2,3-e]indol-2-ylmethyl 4-methylbenzenesulfonate 
• 137578-50-8 2,3-dihydro-2-<<(p-tolylsulfonyl)oxy>methyl>-7H-1,4-dioxino<2,3-e>indole-8-carboxylic acid methyl ester 
• 137578-38-2 8-(2,3-Dihydro-7H-[1,4]dioxino[2,3-e]indol-2-ylmethyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one 
• 137578-26-8 2-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylmethyl)-2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole-8-carbonitrile 
• 137578-39-3 8-(8-Hydroxymethyl-2,3-dihydro-7H-[1,4]dioxino[2,3-e]indol-2-ylmethyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one 
• 137578-24-6 2-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylmethyl)-2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole-8-carboxylic acid 
• 137578-25-7 2-(4-Oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-ylmethyl)-2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole-8-carboxylic acid amide 
• 137578-33-7 2-(4-Carbamoyl-4-phenylamino-piperidin-1-ylmethyl)-2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole-8-carboxylic acid methyl ester 

Relevant academic research and scientific papers

CARBOXYLIC ACID DERIVATIVE AS AT2R RECEPTOR ANTAGONIST

The present invention relates to a compound shown in formula (II) or a pharmaceutically acceptable salt thereof and an application of the same in preparing a drug for treating a disease related to angiotensin II receptor type 2 (AT2R).(II)

HETEROCYCLIC COMPOUNDS AND METHODS OF THEIR USE

The present invention relates generally to compounds that are useful in antagonizing the angiotensin II type 2 (AT2) receptor. More particularly, the invention relates to substituted isoquinoline compounds and their use as AT2 receptor antagonists. Pharmaceutical compositions comprising the compounds and their use in modulating the AT2 receptor and therapies that require modulation of the AT2 receptor are described.

Expeditious synthesis of benzopyrans via lewis acid-catalyzed C-H functionalization: Remarkable enhancement of reactivity by an ortho substituent

An expeditious construction of a benzopyran skeleton via Lewis acid-catalyzed C-H functionalization was achieved. In this process, a [1,5] hydride shift and 6-endo cyclization successively occurred to give benzopyrans. The presence of substituents ortho to the alkoxy group significantly enhanced the reactivity, affording the desired compounds in excellent chemical yields with short reaction times.

(Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors

The present invention provides novel compounds of the Formula (I): A-B, its prodrug forms, or pharmaceutically acceptable salts thereof, wherein A represents a saturated, unsaturated, or a partially unsaturated bicyclic heterocyclic ring structure, and B represents an aryl or a heteroaryl group. Preferred compounds of the present invention comprise a benzimidazole or indole nucleus. The compounds of this invention are inhibitors of serine proteases, Urokinase (uPA), Factor Xa (FXa), and/or Factor VIIa (FVIIa), and have utility as anti cancer agents and/or as anticoagulants for the treatment or prevention of thromboembolic disorders in mammals.

Modulation of selective serotonin reuptake inhibitor and 5-HT1A antagonist activity in 8-aza-bicyclo[3.2.1]octane derivatives of 2,3-dihydro-1,4-benzodioxane

2,3-Dihydro-1,4-benzodioxanes with aryl 8-aza-bicyclo[3.2.1]oct-3-ene attachments 2 produce compounds with potent 5-HT-T affinity, and weak 5-HT 1A affinity and α1 affinity. This compares with 2,3-dihydro-1,4-benzodioxanes containing 8-aza-bicyclo[3.2.1] octan-3-ol attachments 4 which possess potent 5-HT1A affinity, moderate to good selectivity over α1 and little 5-HT-T affinity. A 3-benzothiophene analogue of 4 (30) was synthesized which possesses potent 5-HT1A affinity and especially good selectivity over both α1 and 5-HT-T.

2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

The development of potent and selective urokinase-type plasminogen activator (uPA) inhibitors based on the lead molecule 2-(2-hydroxy-3-ethoxyphenyl)-1H-benzimidazole-5-carboxamidine (3a) is described.

Benzyne Cyclization Route to Benzophenanthridine Alkaloids. Synthesis of Chelerythrine, Decarine, and Nitidine

The alkaloids chelerythrine (8b) and decarine (7c) have been synthesized through a benzyne-mediated cyclization of N-(2-halobenzyl)-1-naphthylamines 4 with KNH2 in ammonia/ether.The 7-hydroxybenzophenanthridine structure 16a proposed for the alkaloid fagaridine is questioned on the basis of comparison with a model compound (16b) synthesized by benzyne cyclization.For the 8,9-oxygenated alkaloids like nitidine (8i), this cyclization proceeded poorly, but a dramatic improvement occurred when LDA/THF at -78 deg C was used instead of KNH2/NH3.

Regioselective Mono-O-alkylation of some Pyrocatechoxide Dianions

In dimethyl sulphoxide the dianions derived from 2,3- or 3,4-dihydroxybenzaldehydes and 4-methylesculetin afford products corresponding to alkylation at the less acidic site while the monoanions give the isomeric phenols.