2-(Benzyloxy)-3-hydroxybenzaldehyde

Base Information

• Chemical Name: 2-(Benzyloxy)-3-hydroxybenzaldehyde
• CAS No.: 86734-60-3
• Molecular Formula: C14H12O3
• Molecular Weight: 228.247
• DSSTox Substance ID: DTXSID70517291
• Nikkaji Number: J1.764.465C
• Wikidata: Q82379209
• Mol file: 86734-60-3.mol

Synonyms:2-(Benzyloxy)-3-hydroxybenzaldehyde;86734-60-3;SCHEMBL4242750;2-benzyloxy-3-hydroxybenzaldehyde;DTXSID70517291;CCHSJXWROPKNDR-UHFFFAOYSA-N;2-benzyloxy-3-hydroxy-benzaldehyde

Chemical Property of 2-(Benzyloxy)-3-hydroxybenzaldehyde

Chemical Property:

• Melting Point: 90-91 °C(Solv: benzene (71-43-2))
• Boiling Point: 170-180 °C(Press: 0.1 Torr)
• PSA: 46.53000
• Density: 1.238±0.06 g/cm3(Predicted)
• LogP: 2.78370
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 228.078644241
• Heavy Atom Count: 17
• Complexity: 236

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=C(C=CC=C2O)C=O

Technology Process of 2-(Benzyloxy)-3-hydroxybenzaldehyde

There total 6 articles about 2-(Benzyloxy)-3-hydroxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2,3-dihydroxybenzaldehyde (24677-78-9) + benzyl bromide (100-39-0) → 2-(benzyloxy)-3-hydroxybenzaldehyde (86734-60-3)

Guidance literature:

2,3-dihydroxybenzaldehyde; With sodium hydride; In tetrahydrofuran; for 0.333333h;

benzyl bromide; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃; for 20.1h;

Reference yield: 44.0%

2,3-dihydroxybenzaldehyde (24677-78-9) + benzyl chloride (100-44-7) → 2-(benzyloxy)-3-hydroxybenzaldehyde (86734-60-3) + 2,3-bis(benzyloxy)benzaldehyde (5779-91-9)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; at 25 ℃; for 17h; Yields of byproduct given; NaH : pyrocatechlol 1.1;

DOI:10.1039/c39830000400

Reference yield:

2-(benzyloxy)-3-(methoxymethoxy)benzaldehyde (1221065-15-1) → 2-(benzyloxy)-3-hydroxybenzaldehyde (86734-60-3)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; at 0 - 20 ℃;

DOI:10.1021/ol100316k

upstream raw materials:

2,3-dihydroxybenzaldehyde

benzyl chloride

benzyl bromide

2-(benzyloxy)-3-(methoxymethoxy)benzaldehyde

Downstream raw materials:

2-benzyloxy-3-methanesulfonyloxy-benzaldehyde

3-(oxiranylmethoxy)-2-(phenylmethoxy)benzaldehyde