3-Chloro-2-methylpropyl(dimethyl)amine

Base Information

• Chemical Name: 3-Chloro-2-methylpropyl(dimethyl)amine
• CAS No.: 23349-86-2
• Molecular Formula: C6H14 Cl N
• Molecular Weight: 135.637
• European Community (EC) Number: 245-598-6
• DSSTox Substance ID: DTXSID00946015
• Nikkaji Number: J26.198J
• Mol file: 23349-86-2.mol

Synonyms:23349-86-2;3-chloro-N,N,2-trimethylpropan-1-amine;3-Chloro-2-methylpropyl(dimethyl)amine;1-Propanamine, 3-chloro-N,N,2-trimethyl-;EINECS 245-598-6;(3-CHLORO-2-METHYLPROPYL)DIMETHYLAMINE;2-methyl-3-dimethylaminopropyl chloride;SCHEMBL2842359;NIOSH/UI0670200;DTXSID00946015;3-dimethylamino-2-methylpropylchloride;AKOS005215794;AKOS022182623;3-Dimethylamino-2-methyl-propylchlorid;3-dimethylamino-2-methylpropyl chloride;3-dimethylamino-2-methyl propyl chloride;1-Chloro-2-methyl-3-dimethylaminopropane;3-Chloro-2,N,N-trimethylpropan-1-amine;3-Chloro-N,N,2-trimethyl-1-propylamine;1-Propylamine, 3-chloro-N,N,2-trimethyl-;3-Chloro-N,N,2-trimethyl-1-propanamine #;LS-125585;UI06702000;EN300-2960954;W-110564

Chemical Property of 3-Chloro-2-methylpropyl(dimethyl)amine

Chemical Property:

• Vapor Pressure: 5.07mmHg at 25°C
• Boiling Point: 144.5°Cat760mmHg
• PKA: 9.19±0.28(Predicted)
• Flash Point: 41.2°C
• PSA: 3.24000
• Density: 0.925g/cm³
• LogP: 1.42290
• Storage Temp.: 2-8°C
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 135.0814771
• Heavy Atom Count: 8
• Complexity: 54.5

Purity/Quality:

99.9% ^*data from raw suppliers

3-Chloro-N,N,2-trimethylpropan-1-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CN(C)C)CCl

Technology Process of 3-Chloro-2-methylpropyl(dimethyl)amine

There total 4 articles about 3-Chloro-2-methylpropyl(dimethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride (4261-67-0) → 3-(dimethylamino)-2-methylpropylchloride (23349-86-2)

Guidance literature:

With sodium hydroxide; In water; pentane; at 20 ℃; for 1h;

Reference yield:

2-methyl-3-dimethylaminopropanol (33622-41-2) → 3-(dimethylamino)-2-methylpropylchloride (23349-86-2)

Guidance literature:

With hydrogenchloride; thionyl chloride; In benzene; for 3h; Heating;

DOI:10.1135/cccc19810597

Reference yield:

1-bromo-3-chloro-2-methyl propane (6974-77-2) + dimethyl amine (124-40-3) → 3-(dimethylamino)-2-methylpropylchloride (23349-86-2)

Guidance literature:

With benzene; at 110 ℃;

DOI:10.1002/hlca.19580410420

upstream raw materials:

2-methyl-3-dimethylaminopropanol

1-bromo-3-chloro-2-methyl propane

dimethyl amine

1-chloro-2-methyl-3-(dimethylamino)propane hydrochloride

Downstream raw materials:

10-<3-Dimethylamino-2-methyl-propyl>-4-aza-phenothiazin

4-Dimethylamino-3-methyl-1,1-diphenyl-butan-1-ol

DL-2-Benzyl-1-(2'-methyl-3'-dimethylaminopropoxyimino)-cyclohexane

N-Benzyl-dithiocarbaminsaeure-(2-methyl-3-dimethylamino-propylester)

Refernces

• 1、 Sindelar,Holubek,Metys,et al.. "Synthesis of 3-(2-alkoxyphenoxy)-2-methyl (or phenyl)propylamines as potential antidepressants". . p. 597 - 606. Retrieved 2007/10/02.