3-CHLOROMETHYL-2,7-DICHLOROQUINOLINE

Base Information

• Chemical Name: 3-CHLOROMETHYL-2,7-DICHLOROQUINOLINE
• CAS No.: 137776-95-5
• Molecular Formula: C10H6Cl3N
• Molecular Weight: 246.52000
• Hs Code.: 2933499090
• Mol file: 137776-95-5.mol

Synonyms:Quinoline,2,7-dichloro-3-(chloromethyl);3-Chloromethyl-2,7-dichloroquinoline;2,7-dichloro-3-(chloromethyl)-quinoline;

Chemical Property of 3-CHLOROMETHYL-2,7-DICHLOROQUINOLINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 365.143oC at 760 mmHg
• Flash Point: 206.134oC
• PSA: 12.89000
• Density: 1.464g/cm3
• LogP: 4.28040

Purity/Quality:

98%min ^*data from raw suppliers

3-Chloromethyl-2,7-dichloroquinoline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25-41
• Safety Statements: 26-39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLOROMETHYL-2,7-DICHLOROQUINOLINE

There total 3 articles about 3-CHLOROMETHYL-2,7-DICHLOROQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2,7-dichloro-3-methylquinoline (132118-46-8) → 2,7-Dichloro-3-chloromethylquinoline (137776-95-5)

Guidance literature:

With phosphorus pentachloride; In various solvent(s); at 150 ℃; for 4h;

Reference yield:

3-chloro-aniline (108-42-9) → 2,7-Dichloro-3-chloromethylquinoline (137776-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene

2: POCl₃ / dimethylformamide

With trichlorophosphate; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/0960-894X(96)00288-0

Reference yield:

3-Chloro-N-(3-chlorophenyl)propanamide (99585-98-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,7-Dichloro-3-chloromethylquinoline (137776-95-5)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1016/0960-894X(96)00288-0

upstream raw materials:

2,7-dichloro-3-methylquinoline

3-Chloro-N-(3-chlorophenyl)propanamide

N,N-dimethyl-formamide

3-chloro-aniline

Refernces

• 1、 Korodi, Ference. "Side-chain Chlorination of Methylquinolines". . p. 1549 - 1552. Retrieved 2007/10/02.