99585-98-5

Basic information

• Product Name: 3-CHLORO-N-(3-CHLOROPHENYL)PROPANAMIDE
• Synonyms: 3-chloro-N-(3-chlorophenyl)propanamide(SALTDATA: FREE);3-chloro-N-(3-chlorophenyl)propionamide;Propanamide, N-(3-chlorophenyl)-3-chloro-;3-CHLORO-N-(3-CHLOROPHENYL)PROPANAMIDE
• CAS NO: 99585-98-5
• Molecular Formula: C₉H₉Cl₂NO
• Molecular Weight: 218.08
• Mol File: 99585-98-5.mol

Chemical Properties

• Boiling Point: 384.5 °C at 760 mmHg
• Flash Point: 186.3 °C
• Appearance: /
• Density: 1.343 g/cm³
• Vapor Pressure: 4.08E-06mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: 3-CHLORO-N-(3-CHLOROPHENYL)PROPANAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-N-(3-CHLOROPHENYL)PROPANAMIDE(99585-98-5)
• EPA Substance Registry System: 3-CHLORO-N-(3-CHLOROPHENYL)PROPANAMIDE(99585-98-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 99585-98-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-chloro-N-(3-chlorophenyl)propanamide is utilized as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, particularly those targeting specific biological pathways or conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 3-chloro-N-(3-chlorophenyl)propanamide serves as an intermediate for the production of pesticides and other crop protection agents. Its chemical properties make it suitable for creating compounds that can effectively manage pests and diseases in agriculture.

InChI:InChI=1/C9H9Cl2NO/c10-5-4-9(13)12-8-3-1-2-7(11)6-8/h1-3,6H,4-5H2,(H,12,13)

Upstream product

• 108-42-9 3-chloro-aniline 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 137776-95-5 2,7-Dichloro-3-chloromethylquinoline 
• 428832-32-0 3-(3,4-dihydroisoquinolin-2(1H)-yl)-N-(3-chlorophenyl)propanamide 
• 1233488-28-2 C₁₁H₁₁ClN₄OS 
• 109507-07-5 N,N-diethyl-β-alanine-(3-chloro-anilide); hydrochloride 

Relevant articles and documents

Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors

Protein arginine methyltransferase 5 (PRMT5) is an epigenetics related enzyme that has been validated as a promising therapeutic target for human cancer. Up to now, two small molecule PRMT5 inhibitors has been put into phase I clinical trial. In the prese

Structural exploration, synthesis and pharmacological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives as iNOS inhibitors against inflammatory diseases

In our previous work, 3I inhibited the LPS-induced iNOS activity and NO production in RAW 264.7 cells and improved joint inflammation and cartilage destruction in inflammatory model. In this study, we synthesized 59 derivatives and bioisosteres on the bas

Synthesis and biological screening of novel derivatives of 3-(N-substituted carboxamidoethylthio)-(4H)-1,2,4-triazoles

3-Mercapto-(4H)-1,2,4-triazole has been synthesized from 1-formylthiosemicarbazide. Different N-substituted β-chloropropionamides have been prepared by reacting substituted amines with β- chloropropionylchloride. Different Nsubstituted β-chloropropionamides have been condensed with 3-mercapto-(4H)-1,2,4-triazole in basic medium to obtain various 3-(N-substituted carboxamidoethylthio)-(4H)-1,2,4-triazoles. The structure of the synthesized compounds are confirmed by IR, 1H NMR spectra and elemental analysis. All the compounds have been screened for their analgesic, anti-inflammatory and anxiolytic activity.

New heteroaryl-spaced phosphono α-amino acids are competitive NMDA antagonists with analgesic activity

The synthesis and the NMDA receptor binding affinities of α-amino-3-(phosphonomethyl)-2-naphthalenepropanoic acid, α-amino-3-(phosphonomethyl)-2-benzofuranpropanoic acid, a series of substituted (R)-α-amino-3-(phosphonomethyl)-2-quinolinepropanoic acids, (R)-α-amino-3-(phosphonomethyl)-1,8-naphthyridine-2-propanoic acid and (R)-α-amino-3-(phosphonomethyl)-1,6-naphthyridine-2-propanoic acid are reported.

5-HT(1A), and D-2 receptor affinity of o-methoxyphenylpiperazine derivatives with terminal benzamide fragment on N-4 alkyl chain. 2

The synthesis of some o-methoxyphenylpiperazines with a benzamide moiety on N-4 alkyl chain was accomplished and their affinity for dopamine and serotonin receptor subtypes was assayed by in vitro receptor binding. The results show that several derivative