N-[Phenyl(trimethylsilyl)methyl]benzamide

Base Information

Chemical Name:N-[Phenyl(trimethylsilyl)methyl]benzamide
CAS No.:138037-04-4
Molecular Formula:C17H21NOSi
Molecular Weight:283.445
Hs Code.:
DSSTox Substance ID:DTXSID201272761
Nikkaji Number:J1.192.732G
Mol file:138037-04-4.mol

Synonyms:DTXSID201272761;138037-04-4;N-[Phenyl(trimethylsilyl)methyl]benzamide

Suppliers and Price of N-[Phenyl(trimethylsilyl)methyl]benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of N-[Phenyl(trimethylsilyl)methyl]benzamide

Chemical Property:

Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:283.139240828
Heavy Atom Count:20
Complexity:311

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C[Si](C)(C)C(C1=CC=CC=C1)NC(=O)C2=CC=CC=C2

Technology Process of N-[Phenyl(trimethylsilyl)methyl]benzamide

There total 3 articles about N-[Phenyl(trimethylsilyl)methyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 75-77-4
chloro-trimethyl-silane

: 724-37-8
2-fluoro-N-(phenylmethyl)benzamide

: 138037-04-4
N-[α-(trimethylsilyl)benzyl]benzamide

Guidance literature:: With tert-butylmagnesium chloride; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; at 50 ℃; for 12h; Schlenk technique; Inert atmosphere;
DOI:10.1021/acs.orglett.6b02784

Reference yield:

: 445-29-4
o-fluoro-benzoic acid

: 138037-04-4
N-[α-(trimethylsilyl)benzyl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 6 h / 20 °C

2: triethylamine / dichloromethane / 3 h / 20 °C

3: 4,4'-di-tert-butyl-2,2'-bipyridine; tert-butylmagnesium chloride / tetrahydrofuran / 12 h / 50 °C / Schlenk technique; Inert atmosphere

With oxalyl dichloride; tert-butylmagnesium chloride; triethylamine; N,N-dimethyl-formamide; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/acs.orglett.6b02784

Reference yield:

: 393-52-2
2-Fluorobenzoyl chloride

: 138037-04-4
N-[α-(trimethylsilyl)benzyl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 20 °C

2: 4,4'-di-tert-butyl-2,2'-bipyridine; tert-butylmagnesium chloride / tetrahydrofuran / 12 h / 50 °C / Schlenk technique; Inert atmosphere

With tert-butylmagnesium chloride; triethylamine; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/acs.orglett.6b02784