2-aMino-6-hydroxy-3-MethoxybenzaMide

Base Information

• Chemical Name: 2-aMino-6-hydroxy-3-MethoxybenzaMide
• CAS No.: 138224-07-4
• Molecular Formula: C8H10N2O3
• Molecular Weight: 182.17700
• Mol file: 138224-07-4.mol

Synonyms:6-hydroxy-3-methoxyanthranilamide;Benzamide,2-amino-6-hydroxy-3-methoxy;

Chemical Property of 2-aMino-6-hydroxy-3-MethoxybenzaMide

Chemical Property:

• PSA: 99.56000
• LogP: 1.54730

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-aMino-6-hydroxy-3-MethoxybenzaMide

There total 4 articles about 2-aMino-6-hydroxy-3-MethoxybenzaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-carbamoyl-3,6-dimethoxyaniline (98991-68-5) → 6-hydroxy-3-methoxyanthranilamide (138224-07-4)

Guidance literature:

With lithium methanethiolate; In N,N-dimethyl-formamide; at 80 ℃; for 14h;

DOI:10.1016/S0040-4020(01)89723-4

Reference yield:

2,5-dimethoxybenzamide (42020-21-3) → 6-hydroxy-3-methoxyanthranilamide (138224-07-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 91.8 percent / 70percent HNO₃ / 0.83 h / 15 °C

2: 96.5 percent / H₂ / 10percent Pd/C / methanol / 3 h

3: 86 percent / LiSMe / dimethylformamide / 14 h / 80 °C

With hydrogen; nitric acid; lithium methanethiolate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)89723-4

Reference yield:

2,5-dimethoxy-6-nitrobenzamide (26002-58-4) → 6-hydroxy-3-methoxyanthranilamide (138224-07-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 96.5 percent / H₂ / 10percent Pd/C / methanol / 3 h

2: 86 percent / LiSMe / dimethylformamide / 14 h / 80 °C

With hydrogen; lithium methanethiolate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)89723-4

upstream raw materials:

2-carbamoyl-3,6-dimethoxyaniline

2,5-dimethoxybenzamide

2,5-dimethoxy-6-nitrobenzamide

methyl 2,5-dimethoxybenzoate

Downstream raw materials:

3-Allyl-6-amino-2-hydroxy-5-methoxy-benzamide

6-hydroxy-3-methoxy-5-propylanthranilamide

2-amino-3-carboxamido-5-propyl-1,4-benzoquinone

2-Amino-3,6-dihydroxy-5-propyl-benzamide

Refernces