3-PIVALOYLTHIAZOLIDINE-2-THION

Base Information

• Chemical Name: 3-PIVALOYLTHIAZOLIDINE-2-THION
• CAS No.: 138459-91-3
• Molecular Formula: C8H13NOS2
• Molecular Weight: 203.329
• Hs Code.: 2934999090
• Mol file: 138459-91-3.mol

Synonyms:2-Thiazolidinethione,3-(2,2-dimethyl-1-oxopropyl);2,2-dimethyl-1-(2-thioxothiazolidin-3-yl)propan-1-one;2,2-Dimethyl-1-(2-thioxo-3-thiazolidinyl)-1-propanone n;

Chemical Property of 3-PIVALOYLTHIAZOLIDINE-2-THION

Chemical Property:

• Boiling Point: 280℃
• PKA: -1.76±0.20(Predicted)
• Flash Point: 123℃
• PSA: 77.70000
• Density: 1.22
• LogP: 1.83070

Purity/Quality:

98%Min ^*data from raw suppliers

2,2-Dimethyl-1-(2-Thioxothiazolidin-3-Yl)Propan-1-One ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: thiazolidin e thione pharmaceutical intermediate

Technology Process of 3-PIVALOYLTHIAZOLIDINE-2-THION

There total 7 articles about 3-PIVALOYLTHIAZOLIDINE-2-THION which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-mercaptothiazoline (96-53-7) + Trimethylacetic acid (75-98-9) → 3-pivaloyl-1,3-thiazolidine-2-thione (138459-91-3)

Guidance literature:

With 2,6-dimethylpyridine; 2-chloro-1,3-dimethylimidazolinium chloride; In dichloromethane; at 20 ℃; for 72h;

DOI:10.1021/jo990210y

Reference yield: 99.0%

→ N-[(Phenyloxy)carbonyl]-10-[(tert-butyldimethylsilyl)oxy]-6-ethy-nyl-3-methoxy-5,6,7,8,9,10-hexahydrophenanthridine + 3-pivaloyl-1,3-thiazolidine-2-thione (138459-91-3)

Guidance literature:

Reference yield: 99.0%

→ N-[(Phenyloxy)carbonyl]-10-[(tertbutyldimethylsilyl)oxy]-6-ethy-nyl-3-methoxy-5,6,7,8,9,10-hexahydrophenanthridine + 3-pivaloyl-1,3-thiazolidine-2-thione (138459-91-3)

Guidance literature:

upstream raw materials:

thiazolidine-2-thione

pivaloyl chloride

sodium 2-mercaptothiazolinate

2-mercaptothiazoline

Downstream raw materials:

N-(2-hydroxyphenyl)-2,2-dimethylpropionamide

Benzoic acid (R)-1-[(1R,5R,7S,8R)-7-bromomethyl-8-(2,2-dimethyl-propionyloxymethyl)-4,7-dimethyl-6-oxa-bicyclo[3.2.1]oct-3-en-5-ylmethyl]-prop-2-ynyl ester

1,1-dimethylethyl 4-[(3-{[(2,2-dimethyl-propanoyl)oxy]-methyl}phenyl)oxy]-piperidine-1-carboxylate

3-hydroxy-4-nitrobenzyl pivalate