Technology Process of N-Hydroxy-N-(4-(5-(4-fluorophenoxy)-2-furyl)-3-butyn-2-yl)urea
There total 7 articles about N-Hydroxy-N-(4-(5-(4-fluorophenoxy)-2-furyl)-3-butyn-2-yl)urea which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) sodium hydride / 1.) THF, 2.) DMF, 0.5h
2: 1.) zinc, triphenylphosphine / 1.) CH2Cl2, overnight, 2.) CH2Cl2, RT, 2 h
3: 50 percent / n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
4: 1.) lithium diisopropylamide / 1.) THF, -5 deg C, 0.5 h, 2.) THF, from -5 deg C to RT
5: 53 percent / triphenylphosphine, diisopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / Ambient temperature
6: 57 percent / ammonia / -78 - 20 °C
With
n-butyllithium; di-isopropyl azodicarboxylate; ammonia; sodium hydride; triphenylphosphine; zinc; lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
DOI:10.1021/jm00024a004
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) zinc, triphenylphosphine / 1.) CH2Cl2, overnight, 2.) CH2Cl2, RT, 2 h
2: 50 percent / n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
3: 1.) lithium diisopropylamide / 1.) THF, -5 deg C, 0.5 h, 2.) THF, from -5 deg C to RT
4: 53 percent / triphenylphosphine, diisopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / Ambient temperature
5: 57 percent / ammonia / -78 - 20 °C
With
n-butyllithium; di-isopropyl azodicarboxylate; ammonia; triphenylphosphine; zinc; lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
DOI:10.1021/jm00024a004
