Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroeth oxy)ethyl]-, 3'-(hydrogen butanedioate)

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Chemical Name:Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroeth oxy)ethyl]-, 3'-(hydrogen butanedioate)
CAS No.:138494-35-6
Molecular Formula:C46H46ClN5O11
Molecular Weight:880.351
Hs Code.:

Synonyms:

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Chemical Property of Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroeth oxy)ethyl]-, 3'-(hydrogen butanedioate)

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Technology Process of Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroeth oxy)ethyl]-, 3'-(hydrogen butanedioate)

There total 5 articles about Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[1-(2-chloroeth oxy)ethyl]-, 3'-(hydrogen butanedioate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 108-30-5
succinic acid anhydride

: 138078-31-6
6-N-benzoyl-2'-O-(1-(2-chloroethoxy)ethyl)-5'-O-dimethoxytrityladenosine

: 138494-35-6
Succinic acid mono-{(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(2-chloro-ethoxy)-ethoxy]-tetrahydro-furan-3-yl} ester

Guidance literature:: With dmap; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1016/S0040-4020(01)96193-9

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 138494-35-6
Succinic acid mono-{(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(2-chloro-ethoxy)-ethoxy]-tetrahydro-furan-3-yl} ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / pyridine

2: 85 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; dmap; In dichloromethane;
DOI:10.1016/S0040-4020(01)96193-9

Reference yield:

: 79154-57-7
3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N₆-benzoyladenosine

: 138494-35-6
Succinic acid mono-{(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[1-(2-chloro-ethoxy)-ethoxy]-tetrahydro-furan-3-yl} ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridinium p-toluenesulfonate / CH₂Cl₂ / Ambient temperature

2: tetraethylammonium hydrogen fluoride / tetrahydrofuran / 1.5 h

3: 87 percent / pyridine

4: 85 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; dmap; pyridinium p-toluenesulfonate; tetraethylammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)96193-9