2-(4-METHOXY-PHENOXY)-2-METHYL-PROPIONIC ACID

Base Information

• Chemical Name: 2-(4-METHOXY-PHENOXY)-2-METHYL-PROPIONIC ACID
• CAS No.: 17509-54-5
• Molecular Formula: C11H14O4
• Molecular Weight: 210.23
• Hs Code.: 2918990090
• Mol file: 17509-54-5.mol

Synonyms:2-(2-PHENOXYETHOXY)-N-(4-PROPOXYBENZYL)ANILINE;2-(4-Methoxy-phenoxy)-2-methyl-propionic acid;2-(4-Methoxyphenoxy)-2-methyl-Propanoicacid;

Chemical Property of 2-(4-METHOXY-PHENOXY)-2-METHYL-PROPIONIC ACID

Chemical Property:

• Vapor Pressure: 4.16E-05mmHg at 25°C
• Boiling Point: 337.2°Cat760mmHg
• Flash Point: 128.8°C
• PSA: 55.76000
• Density: 1.157g/cm³
• LogP: 1.93720

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Methoxyphenoxy)-2-methylpropanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-METHOXY-PHENOXY)-2-METHYL-PROPIONIC ACID

There total 7 articles about 2-(4-METHOXY-PHENOXY)-2-METHYL-PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-bromo-2-methylpropionic acid (2052-01-9) + 4-methoxy-phenol (150-76-5) → α-(4-methoxyphenoxy)-2-methylpropionic acid (17509-54-5)

Guidance literature:

4-methoxy-phenol; With sodium hydroxide; In butanone; at 50 ℃; for 1h;

2-bromo-2-methylpropionic acid; In butanone; at 50 ℃; for 0.5h;

DOI:10.1055/s-2004-829171

Reference yield: 70.0%

4-methoxy-phenol (150-76-5) + 1,1,1-trichloro-2-methyl-2-propanol (57-15-8) → α-(4-methoxyphenoxy)-2-methylpropionic acid (17509-54-5)

Guidance literature:

With sodium hydroxide; water; In acetone; at 20 ℃; for 18h;

DOI:10.1021/jo020023r

Reference yield:

2-(4-methoxyphenoxy)acetic acid (1877-75-4) → α-(4-methoxyphenoxy)-2-methylpropionic acid (17509-54-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 23 percent / 2,6-lutidine; LiClO₄ / acetonitrile / Electrochemical reaction

2: 70 percent / NaOH; H₂O / acetone / 18 h / 20 °C

With 2,6-dimethylpyridine; sodium hydroxide; water; lithium perchlorate; In acetone; acetonitrile;

DOI:10.1021/jo020023r

upstream raw materials:

4-methoxy-phenol

acetone

1,1,1-trichloro-2-methyl-2-propanol

2-bromo-2-methylpropionic acid

Downstream raw materials:

2-(4-methoxyphenoxy)-2-methyl-propionyl-cyanomethylenetriphenylphosphorane

4,4-dimethoxycyclohexa-2,5-dienone

3,3-dimethyl-1,4-dioxospiro[4.5]deca-6,9-diene-2,8-dione

p-benzoquinone

Refernces

• 1、 Green, James R.,St. Onge, Brent. "The formation of benzoxacin-3-ones: Via intramolecular Nicholas reactions and synthesis of 8-membered heliannuols". supporting information. p. 7152 - 7155. Retrieved 2021/08/30.
• 2、 Huang, Bin,Huang, Pei-Gang,Sheng, Shou-Ri,Wang, Qiu-Ying,Guo, Lei,Jiang, Shao-Hua. "Liquid-phase synthesis of 2-methyl-2-aryloxypropanoic acid derivatives from poly(ethylene glycol) supported 2-bromo-2-methylpropanoate". . p. 575 - 578. Retrieved 2008/02/11.