Ethyl 2-(4-methoxyphenoxy)-2-methylpropanoate

Base Information

• Chemical Name: Ethyl 2-(4-methoxyphenoxy)-2-methylpropanoate
• CAS No.: 18672-05-4
• Molecular Formula: C₁₃H₁₈O₄
• Molecular Weight: 238.284
• DSSTox Substance ID: DTXSID50364164
• Wikidata: Q82147961
• Mol file: 18672-05-4.mol

Synonyms:ethyl 2-(4-methoxyphenoxy)-2-methylpropanoate;18672-05-4;Propanoic acid, 2-(4-methoxyphenoxy)-2-methyl-, ethyl ester;SCHEMBL7979408;DTXSID50364164;STK443096;AKOS003331065

Chemical Property of Ethyl 2-(4-methoxyphenoxy)-2-methylpropanoate

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 238.12050905
• Heavy Atom Count: 17
• Complexity: 242

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(C)(C)OC1=CC=C(C=C1)OC

Technology Process of Ethyl 2-(4-methoxyphenoxy)-2-methylpropanoate

There total 4 articles about Ethyl 2-(4-methoxyphenoxy)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α-(4-methoxyphenoxy)-2-methylpropionic acid (17509-54-5) → α-(4-methoxy-phenoxy)-isobutyric acid ethyl ester (18672-05-4)

Guidance literature:

With sulfuric acid;

Reference yield:

4-methoxy-phenol (150-76-5) → α-(4-methoxy-phenoxy)-isobutyric acid ethyl ester (18672-05-4)

Guidance literature:

Multi-step reaction with 2 steps

1: CHCl₃; NaOH

2: ethanolic H₂SO₄

With sodium hydroxide; chloroform; sulfuric acid;

Reference yield:

chloroform (67-66-3,8013-54-5) + 4-methoxy-phenol (150-76-5) + acetone (67-64-1) → α-(4-methoxy-phenoxy)-isobutyric acid ethyl ester (18672-05-4)

Guidance literature:

Multistep reaction; (i) NaOH, (ii) (esterification);

DOI:10.1021/jm00311a048

upstream raw materials:

α-(4-methoxyphenoxy)-2-methylpropionic acid

chloroform

4-methoxy-phenol

acetone