Technology Process of 1H-Pyrrole-2-carboxylic acid,
4-ethyl-5-[[4-(methoxycarbonyl)-3,5-dimethyl-1H-pyrrol-2-yl]methyl]-,
phenylmethyl ester
There total 6 articles about 1H-Pyrrole-2-carboxylic acid,
4-ethyl-5-[[4-(methoxycarbonyl)-3,5-dimethyl-1H-pyrrol-2-yl]methyl]-,
phenylmethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
acetic acid;
at 100 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium nitrite, acetic acid / H2O / 5 °C
2: Zn, acetic acid / H2O / 1 h / 100 °C
3: 74 percent / tin(II) chloride dihydrate / 1.) 55 deg C, 5 min, 2.) RT, 1 h
4: 1.) sodium borohydride, 2.) BF3*Et2O / 1.) THF, 5 deg C, 2.) THF, 1 h
5: 60 percent / acetic acid, acetic anhydride / 2.5 h / Ambient temperature
6: 92 percent / acetic acid / 1 h / 100 °C
With
sodium tetrahydroborate; boron trifluoride diethyl etherate; acetic anhydride; acetic acid; tin(ll) chloride; zinc; sodium nitrite;
In
water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: Zn, acetic acid / H2O / 1 h / 100 °C
2: 74 percent / tin(II) chloride dihydrate / 1.) 55 deg C, 5 min, 2.) RT, 1 h
3: 1.) sodium borohydride, 2.) BF3*Et2O / 1.) THF, 5 deg C, 2.) THF, 1 h
4: 60 percent / acetic acid, acetic anhydride / 2.5 h / Ambient temperature
5: 92 percent / acetic acid / 1 h / 100 °C
With
sodium tetrahydroborate; boron trifluoride diethyl etherate; acetic anhydride; acetic acid; tin(ll) chloride; zinc;
In
water;
