2,3,4,5-Tetrahydro-6-[[(R)-(4-methylphenyl)sulfinyl]methyl]pyridine

Base Information

Chemical Name:2,3,4,5-Tetrahydro-6-[[(R)-(4-methylphenyl)sulfinyl]methyl]pyridine
CAS No.:138713-56-1
Molecular Formula:C13H17NOS
Molecular Weight:235.35
Hs Code.:
DSSTox Substance ID:DTXSID101161460

Synonyms:DTXSID101161460;2,3,4,5-Tetrahydro-6-[[(R)-(4-methylphenyl)sulfinyl]methyl]pyridine;138713-56-1

Suppliers and Price of 2,3,4,5-Tetrahydro-6-[[(R)-(4-methylphenyl)sulfinyl]methyl]pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 2,3,4,5-Tetrahydro-6-[[(R)-(4-methylphenyl)sulfinyl]methyl]pyridine

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:235.10308534
Heavy Atom Count:16
Complexity:280

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)CC2=NCCCC2
Isomeric SMILES:CC1=CC=C(C=C1)[S@](=O)CC2=NCCCC2

Technology Process of 2,3,4,5-Tetrahydro-6-[[(R)-(4-methylphenyl)sulfinyl]methyl]pyridine

There total 3 articles about 2,3,4,5-Tetrahydro-6-[[(R)-(4-methylphenyl)sulfinyl]methyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 260561-02-2
(R)-(4-t-butoxycarbonylamino)butyl p-tolylsulfinylmethyl ketone

: 138713-56-1
(+)-2,3,4,5-Tetrahydro-6-<(R)-(4-methylphenyl)sulfinylmethyl>pyridine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/S0957-4166(99)00523-6

Reference yield:

: 675-20-7
piperidin-2-one

: 138713-56-1
(+)-2,3,4,5-Tetrahydro-6-<(R)-(4-methylphenyl)sulfinylmethyl>pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 48 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 24 h / 20 °C

2.1: LDA / tetrahydrofuran / 0.5 h / 0 °C

2.2: 89 percent / tetrahydrofuran / 1 h / -78 °C

3.1: 60 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

With dmap; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 1.1: Acylation / 2.1: Metallation / 2.2: Condensation / 3.1: Cyclization;
DOI:10.1016/S0957-4166(99)00523-6

Reference yield:

: 85908-96-9
2-oxopiperidine-1-carboxylic acid tert-butyl ester

: 138713-56-1
(+)-2,3,4,5-Tetrahydro-6-<(R)-(4-methylphenyl)sulfinylmethyl>pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / 0.5 h / 0 °C

1.2: 89 percent / tetrahydrofuran / 1 h / -78 °C

2.1: 60 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

With trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 1.1: Metallation / 1.2: Condensation / 2.1: Cyclization;
DOI:10.1016/S0957-4166(99)00523-6