2-(3,4,5-Trimethoxyphenyl)-5-methoxytetrahydrofuran

Base Information

Chemical Name:2-(3,4,5-Trimethoxyphenyl)-5-methoxytetrahydrofuran
CAS No.:138745-81-0
Molecular Formula:C14H20O5
Molecular Weight:268.31
Hs Code.:
DSSTox Substance ID:DTXSID201219923

Synonyms:SCHEMBL9263094;NTWKVIBNQRPRRL-UHFFFAOYSA-N;DTXSID201219923;138745-81-0;2-(3,4,5-trimethoxyphenyl)-5 -methoxytetrahydrofuran;Tetrahydro-2-methoxy-5-(3,4,5-trimethoxyphenyl)furan

Suppliers and Price of 2-(3,4,5-Trimethoxyphenyl)-5-methoxytetrahydrofuran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(3,4,5-Trimethoxyphenyl)-5-methoxytetrahydrofuran

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:268.13107373
Heavy Atom Count:19
Complexity:259

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1CCC(O1)C2=CC(=C(C(=C2)OC)OC)OC

Technology Process of 2-(3,4,5-Trimethoxyphenyl)-5-methoxytetrahydrofuran

There total 3 articles about 2-(3,4,5-Trimethoxyphenyl)-5-methoxytetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 138745-73-0
2-methoxy-5-phenylsulfonyltetrahydrofuran

: magnesium bromide diethyl etherate

: 2675-79-8
1-bromo-3,4,5-trimethoxybenzene

: 7699-45-8
zinc dibromide

: 138745-81-0
tetrahydro-2-methoxy-5-(3,4,5-trimethoxyphenyl)furan

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane;

Reference yield:

: 696-59-3
cis,trans-2,5-dimethoxytetrahydrofuran

: 138745-81-0
tetrahydro-2-methoxy-5-(3,4,5-trimethoxyphenyl)furan

Guidance literature:: Multi-step reaction with 2 steps

1: 28 percent / CaCl₂ / CH₂Cl₂ / 24 h / Ambient temperature

2: 1.) t-BuLi, 2.) ZnBr₂, MgBr₂:Et₂O, / 1.) THF, pentane, -90 deg C, 10 min, 2.) THF, RT; 30 min, 3.) THF, 20 h,

With tert.-butyl lithium; calcium chloride; magnesium bromide; zinc dibromide; In dichloromethane;
DOI:10.1016/S0040-4020(01)81323-5

Reference yield:

: 2675-79-8
1-bromo-3,4,5-trimethoxybenzene

: 125375-29-3,125375-31-7,138745-73-0
cis-2-(benzenesulphonyl)tetrahydro-5-methoxyfuran

: 138745-81-0
tetrahydro-2-methoxy-5-(3,4,5-trimethoxyphenyl)furan

Guidance literature:: With tert.-butyl lithium; magnesium bromide; zinc dibromide; Yield given. Multistep reaction; 1.) THF, pentane, -90 deg C, 10 min, 2.) THF, RT; 30 min, 3.) THF, 20 h,;
DOI:10.1016/S0040-4020(01)81323-5