Manozodil

Base Information

Chemical Name:Manozodil
CAS No.:77528-67-7
Molecular Formula:C10H16 N2 S
Molecular Weight:196.316
Hs Code.:2934999090
European Community (EC) Number:278-713-3
UNII:GZM2484VQ4
DSSTox Substance ID:DTXSID40998730
Nikkaji Number:J32.495G
Wikidata:Q27279381
NCI Thesaurus Code:C74415
ChEMBL ID:CHEMBL2104686
Mol file:77528-67-7.mol

Synonyms:Manozodil;77528-67-7;Manozodil [INN];Manozodilum;Manozodilum [INN-Latin];UNII-GZM2484VQ4;N-methyl-1-(2-methyl-4,5,6,7-tetrahydro-1,3-benzothiazol-5-yl)methanamine;GZM2484VQ4;EINECS 278-713-3;4,5,6,7-Tetrahydro-2-methyl-5-((methylamino)methyl)benzothiazole;5-Benzothiazolemethanamine, 4,5,6,7-tetrahydro-N,2-dimethyl-;SCHEMBL2109903;3,4-Dimethoxybenzyl acetontrile;CHEMBL2104686;DTXSID40998730;AKOS006273980;FT-0692367;Q27279381;methyl[(2-methyl-4,5,6,7-tetrahydro-1,3-benzothiazol-5-yl)methyl]amine

Suppliers and Price of Manozodil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
MANOZODIL 95.00%
5MG
$ 498.36

Total 4 raw suppliers

Chemical Property of Manozodil

Chemical Property:

Vapor Pressure:0.000929mmHg at 25°C
Boiling Point:303.5°C at 760 mmHg
Flash Point:137.3°C
PSA：53.16000
Density:1.08g/cm³
LogP:2.16670
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:196.10341969
Heavy Atom Count:13
Complexity:174

Purity/Quality:

99% ^*data from raw suppliers

MANOZODIL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC2=C(S1)CCC(C2)CNC

Technology Process of Manozodil

There total 7 articles about Manozodil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 77528-66-6
methyl-2 tosyloxymethyl-5 tetrahydro-4,5,6,7 benzothiazole

: 74-89-5
methylamine

: 77528-67-7
methyl-2 N methylamino methyl-5 tetrahydro-4,5,6,7 benzothiazole

Guidance literature:: In methanol; at 90 ℃; for 20h;

Reference yield:

: 7781-98-8
ethyl-3-hydroxybenzoate

: 77528-67-7
methyl-2 N methylamino methyl-5 tetrahydro-4,5,6,7 benzothiazole

Guidance literature:: Multi-step reaction with 7 steps

1: 83 percent / H₂ / Ru/C / ethanol / 18 h / 120 °C / 75005.9 Torr

2: 93.5 percent / CrO₃, H₂SO₄ / acetone; H₂O / 5 - 10 °C

3: Br₂ / diethyl ether / 5 °C

4: 53 percent / dimethylformamide / 16 h / Ambient temperature

5: 95 percent / LiAlH₄ / diethyl ether / 35 h / Ambient temperature

6: 75 percent / pyridine / 16 h

7: 77 percent / methanol / 20 h / 90 °C

With chromium(VI) oxide; lithium aluminium tetrahydride; sulfuric acid; hydrogen; bromine; Ru-carbon; In pyridine; methanol; diethyl ether; ethanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 33668-25-6
ethyl 3-oxocyclohexanecarboxylate

: 77528-67-7
methyl-2 N methylamino methyl-5 tetrahydro-4,5,6,7 benzothiazole

Guidance literature:: Multi-step reaction with 5 steps

1: Br₂ / diethyl ether / 5 °C

2: 53 percent / dimethylformamide / 16 h / Ambient temperature

3: 95 percent / LiAlH₄ / diethyl ether / 35 h / Ambient temperature

4: 75 percent / pyridine / 16 h

5: 77 percent / methanol / 20 h / 90 °C

With lithium aluminium tetrahydride; bromine; In pyridine; methanol; diethyl ether; N,N-dimethyl-formamide;