3-Amino-1H-indole-2-carbohydrazide

Base Information

• Chemical Name: 3-Amino-1H-indole-2-carbohydrazide
• CAS No.: 110963-29-6
• Molecular Formula: C9H10N4O
• Molecular Weight: 190.205
• Hs Code.: 2933990090
• Mol file: 110963-29-6.mol

Synonyms:3-aminoindol-2-carbohydrazide;

Chemical Property of 3-Amino-1H-indole-2-carbohydrazide

Chemical Property:

• Melting Point: 197-199 °C
• Refractive Index: 1.78
• PKA: 13.71±0.30(Predicted)
• PSA: 96.93000
• Density: 1.444 g/cm³
• LogP: 2.02600

Purity/Quality:

98%Min ^*data from raw suppliers

3-Amino-1H-indole-2-carbohydrazide >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Amino-1H-indole-2-carbohydrazide

There total 3 articles about 3-Amino-1H-indole-2-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

ethyl 3-amino-1H-indole-2-carboxylate (87223-77-6) → 3-Aminoindole-2-carbohydrazide (110963-29-6)

Guidance literature:

With hydrazine hydrate; for 4h; Heating;

DOI:10.1002/jhet.5570280304

Reference yield: 35.0%

ethyl 3-(benzoylamino)-1H-indole-2-carboxylate (110963-25-2) → 3-Aminoindole-2-carbohydrazide (110963-29-6)

Guidance literature:

With hydrazine hydrate; for 2h; Heating;

DOI:10.1002/jhet.5570240226

Reference yield:

→ 4-methyl-benzaldehyde (104-87-0) + 3-Aminoindole-2-carbohydrazide (110963-29-6)

Guidance literature:

upstream raw materials:

ethyl 3-amino-1H-indole-2-carboxylate

ethyl 3-(benzoylamino)-1H-indole-2-carboxylate

Downstream raw materials:

3-Amino-1H-indole-2-carboxylic acid [1-(4-phenoxy-phenyl)-meth-(E)-ylidene]-hydrazide

3-{[1-(4-Phenoxy-phenyl)-meth-(E)-ylidene]-amino}-1H-indole-2-carboxylic acid [1-(4-phenoxy-phenyl)-meth-(E)-ylidene]-hydrazide

3-Amino-indole-2-carboxylic acid (4-methylbenzylidene)-hydrazide

3-{[1-p-Tolyl-meth-(E)-ylidene]-amino}-1H-indole-2-carboxylic acid [1-p-tolyl-meth-(E)-ylidene]-hydrazide

Refernces

• 1、 Monge,Aldana,Font,Arraras,Santiago,Lopez-Unzu,Martinez de Irujo,Alberdi. "New indole and triazino[5,4-b]indol-4-one derivatives: Synthesis and studies as inotropics and inhibitors of blood platelet aggregation". . p. 439 - 452. Retrieved 2007/10/02.
• 2、 Monge,Palop,Parrado,et al.. "Synthesis of 3-amino-5H-pyrimido[5,4-b]indol-4-one derivatives". . p. 437 - 439. Retrieved 2007/10/02.